Document Detail

S-nitrosoglutathione modulates CXCR4 and ICOS expression.
MedLine Citation:
PMID:  16847746     Owner:  NLM     Status:  MEDLINE    
The expression of CXCR4, a membrane protein which is involved in the entry of HIV-1, is down-modulated from the cell surface by Phorbol 12-myristate 13-acetate (PMA) and the Ca+ ionophore, Ionomycin. Inducible co-stimulator (ICOS), which contributes to lymphocyte proliferation, is up-regulated by PMA/Ionomycin. We examined the influence of S-nitrosoglutathione (SNG), an inhibitor of Vacuolar H+-ATPase (V-ATPase), on the expression of CXCR4 and ICOS in PMA/Ionomycin-treated peripheral mononuclear cells (PBMC), and of CXCR4 alone in lymphoid cell lines. In this report, we show that SNG interferes with both effects of PMA/Ionomycin, namely CXCR4 down-regulation and ICOS up-regulation. These studies imply opposing roles of V-ATPase in the regulation of CXCR4 and ICOS. The influence of SNG in modulating the susceptibility of T cells to HIV-1 and on their immune responses needs further investigation.
Yoshihiko Yamamoto; Rajendra Pahwa; Savita Pahwa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cellular & molecular biology letters     Volume:  11     ISSN:  1689-1392     ISO Abbreviation:  Cell. Mol. Biol. Lett.     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-18     Completed Date:  2009-07-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607427     Medline TA:  Cell Mol Biol Lett     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  30-6     Citation Subset:  IM    
Department of Pediatrics, North Shore-LIJ Research Institute, Immunology & Inflammation Center of Excellence, New York University School of Medicine, Manhasset, NY 11030, USA.
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MeSH Terms
Antigens, Differentiation, T-Lymphocyte / biosynthesis,  genetics*,  metabolism*
Cell Line, Tumor
Down-Regulation / drug effects
Gene Expression Regulation / drug effects*
Jurkat Cells
Nitric Oxide Donors / pharmacology*
Receptors, CXCR4 / biosynthesis*,  genetics*
S-Nitrosoglutathione / pharmacology*
Up-Regulation / drug effects
Reg. No./Substance:
0/Antigens, Differentiation, T-Lymphocyte; 0/Cxcr4 protein, rat; 0/Nitric Oxide Donors; 0/Receptors, CXCR4; 0/inducible T-cell co-stimulator; 57564-91-7/S-Nitrosoglutathione

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