| S-ketamine and GABA-A-receptor interaction in humans: an exploratory study with I-123-iomazenil SPECT. | |
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MedLine Citation:
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PMID: 18546441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We aimed to probe for regional cerebral effects of S-ketamine on in vivo GABA-A-receptor binding in healthy human subjects. METHODS: We investigated I-123-iomazenil SPECT before, during and after administration of S-ketamine in a blinded placebo-controlled study design (n = 12 in both groups). Analyses of SPECT were performed with voxel-based statistical parametric mapping (SPM), and statistical comparisons were made between the groups. We also assessed biochemical and behavioural changes during S-ketamine infusion. RESULTS: S-ketamine induced positive and negative symptoms measured by the Brief Psychiatric Rating scale (BPRS). It increased the cortisol and prolactin levels. Image analysis revealed significantly decreased I-123-iomazenil binding in bilateral dorsomedial prefrontal cortex during S-ketamine administration when compared to placebo. CONCLUSION: Our study delivers preliminary evidence for an in vivo interaction of S-ketamine with GABA-A-receptors in human dorsomedial prefrontal cortex. |
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Authors:
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Alexander Heinzel; Rainer Steinke; Thorsten Dirk Poeppel; Oliver Grosser; Bernhard Bogerts; Hans Otto; Georg Northoff |
Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human psychopharmacology Volume: 23 ISSN: 1099-1077 ISO Abbreviation: Hum Psychopharmacol Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-06 Completed Date: 2009-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8702539 Medline TA: Hum Psychopharmacol Country: England |
Other Details:
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Languages: eng Pagination: 549-54 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Magdeburg, Magdeburg, Germany. a.heinzel@fz-juelich.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Anesthetics, Dissociative / blood, pharmacology* Brain Mapping Brief Psychiatric Rating Scale Case-Control Studies Cerebral Cortex / drug effects*, radionuclide imaging* Female Flumazenil / analogs & derivatives Humans Hydrocortisone / blood Iodine Radioisotopes Ketamine / blood, pharmacology* Male Prolactin / blood Receptors, GABA-A / physiology* Tomography, Emission-Computed, Single-Photon* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Dissociative; 0/Iodine Radioisotopes; 0/Receptors, GABA-A; 127396-36-5/iomazenil; 50-23-7/Hydrocortisone; 6740-88-1/Ketamine; 78755-81-4/Flumazenil; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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