Document Detail


S-ketamine and GABA-A-receptor interaction in humans: an exploratory study with I-123-iomazenil SPECT.
MedLine Citation:
PMID:  18546441     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We aimed to probe for regional cerebral effects of S-ketamine on in vivo GABA-A-receptor binding in healthy human subjects. METHODS: We investigated I-123-iomazenil SPECT before, during and after administration of S-ketamine in a blinded placebo-controlled study design (n = 12 in both groups). Analyses of SPECT were performed with voxel-based statistical parametric mapping (SPM), and statistical comparisons were made between the groups. We also assessed biochemical and behavioural changes during S-ketamine infusion. RESULTS: S-ketamine induced positive and negative symptoms measured by the Brief Psychiatric Rating scale (BPRS). It increased the cortisol and prolactin levels. Image analysis revealed significantly decreased I-123-iomazenil binding in bilateral dorsomedial prefrontal cortex during S-ketamine administration when compared to placebo. CONCLUSION: Our study delivers preliminary evidence for an in vivo interaction of S-ketamine with GABA-A-receptors in human dorsomedial prefrontal cortex.
Authors:
Alexander Heinzel; Rainer Steinke; Thorsten Dirk Poeppel; Oliver Grosser; Bernhard Bogerts; Hans Otto; Georg Northoff
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human psychopharmacology     Volume:  23     ISSN:  1099-1077     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2009-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  549-54     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany. a.heinzel@fz-juelich.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Anesthetics, Dissociative / blood,  pharmacology*
Brain Mapping
Brief Psychiatric Rating Scale
Case-Control Studies
Cerebral Cortex / drug effects*,  radionuclide imaging*
Female
Flumazenil / analogs & derivatives
Humans
Hydrocortisone / blood
Iodine Radioisotopes
Ketamine / blood,  pharmacology*
Male
Prolactin / blood
Receptors, GABA-A / physiology*
Tomography, Emission-Computed, Single-Photon*
Young Adult
Chemical
Reg. No./Substance:
0/Anesthetics, Dissociative; 0/Iodine Radioisotopes; 0/Receptors, GABA-A; 127396-36-5/iomazenil; 50-23-7/Hydrocortisone; 6740-88-1/Ketamine; 78755-81-4/Flumazenil; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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