| S-cone pathway sensitivity in diabetes measured with threshold versus intensity curves on flashed backgrounds. | |
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MedLine Citation:
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PMID: 8595969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To study sensitivity loss to short wavelength lights in patients with diabetes with or without retinopathy and to identify changes that cannot be attributed to preretinal screening. METHODS: Flash-on-flash thresholds were measured in 41 patients with diabetes and were compared to those in age-matched normals. A 50-ms, 1 degree blue test spot was presented simultaneously with a 500-ms, 2 degree blue flash. A bright yellow background isolated the S-cone system. RESULTS: The mean flash-on-flash threshold curve shifted up as the stage of retinopathy progressed in 16 patients with insulin-dependent diabetes mellitus (IDDM), including those without retinopathy. In 25 patients with noninsulin-dependent diabetes mellitus (NIDDM), those with preproliferative retinopathy revealed sensitivity loss; however, those with background retinopathy or without retinopathy showed no statistically significant change in sensitivity. CONCLUSIONS: The pattern of sensitivity loss in the patients with IDDM cannot be caused by changes in preretinal screening, including yellowing of the lens. Further, early functional changes in the patients with IDDM without retinopathy can be detected by this method. |
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Authors:
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H Terasaki; H Hirose; Y Miyake |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 37 ISSN: 0146-0404 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-04-16 Completed Date: 1996-04-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 680-4 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Nagoya University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Color Perception / physiology Diabetes Mellitus, Type 1 / physiopathology Diabetes Mellitus, Type 2 / physiopathology Diabetic Retinopathy / physiopathology* Humans Middle Aged Photic Stimulation Retinal Cone Photoreceptor Cells / physiology* Sensory Thresholds / physiology* Visual Pathways / physiology* |
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