| S-allylcysteine inhibits circulatory lipid peroxidation and promotes antioxidants in N-nitrosodiethylamine-induced carcinogenesis. | |
| | |
MedLine Citation:
|
PMID: 12856824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Effects of S-allylcysteine (SAC), an organosulfur compound of garlic, on circulatory lipid peroxidation and antioxidant levels were evaluated in N-nitrosodiethylamine (NEDA)-induced hepatocarcinogenesis in Wistar rats. Significantly elevated thiobarbituric acid reactive substances in the circulation of rats bearing carcinoma indicated the higher levels of lipid peroxidation which was accompanied by significantly decreased levels of antioxidants (beta-carotene, ascorbic acid, alpha-tocopherol, reduced glutathione, glutathione peroxidase, superoxide dismutase and catalase) when compared with controls. Lipid peroxidation has been implicated as a major cause in cancer development. SAC-administered rats showed the inhibition of tumor incidence and lipid peroxidation with simultaneous elevation in antioxidants. We suggest that SAC exerts its chemopreventive effects by decreasing lipid peroxidation and enhancing the levels of antioxidants in NDEA carcinogenesis by reducing the formation of free radicals. |
| | |
Authors:
|
Sivapatham Sundaresan; Perumal Subramanian |
Related Documents
:
|
1864524 - In vivo breath alkane as an index of lipid peroxidation. 21348474 - Lewis acid-mediated michaelis-arbuzov reaction at room temperature: a facile preparatio... 3345574 - Hemoglobin-catalyzed transformation of elliptinium acetate into electrophilic species. ... 1869544 - Perhydroxyl radical (hoo.) initiated lipid peroxidation. the role of fatty acid hydrope... 31754 - Effects of bile acids, antacids, and cholestyramine on transmural electrical potential ... 1115754 - Jejunal absorption of an amino acid mixture simulating casein and an enzymic hydrolysat... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Polish journal of pharmacology Volume: 55 ISSN: 1230-6002 ISO Abbreviation: Pol J Pharmacol Publication Date: 2003 Jan-Feb |
Date Detail:
|
Created Date: 2003-07-14 Completed Date: 2004-02-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9313882 Medline TA: Pol J Pharmacol Country: Poland |
Other Details:
|
Languages: eng Pagination: 37-42 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antioxidants / metabolism* Carcinogenicity Tests / methods Cysteine / analogs & derivatives*, pharmacology*, therapeutic use Diethylnitrosamine / toxicity* Lipid Peroxidation / drug effects*, physiology Liver Neoplasms, Experimental / chemically induced, metabolism*, prevention & control Male Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 21593-77-1/S-allylcysteine; 52-90-4/Cysteine; 55-18-5/Diethylnitrosamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enhancement of circulatory antioxidants by alpha-ketoglutarate during sodium valproate treatment in ...
Next Document: Effect of Casearia esculenta root extract on blood glucose and plasma antioxidant status in streptoz...