Document Detail

S-allylcysteine inhibits circulatory lipid peroxidation and promotes antioxidants in N-nitrosodiethylamine-induced carcinogenesis.
MedLine Citation:
PMID:  12856824     Owner:  NLM     Status:  MEDLINE    
Effects of S-allylcysteine (SAC), an organosulfur compound of garlic, on circulatory lipid peroxidation and antioxidant levels were evaluated in N-nitrosodiethylamine (NEDA)-induced hepatocarcinogenesis in Wistar rats. Significantly elevated thiobarbituric acid reactive substances in the circulation of rats bearing carcinoma indicated the higher levels of lipid peroxidation which was accompanied by significantly decreased levels of antioxidants (beta-carotene, ascorbic acid, alpha-tocopherol, reduced glutathione, glutathione peroxidase, superoxide dismutase and catalase) when compared with controls. Lipid peroxidation has been implicated as a major cause in cancer development. SAC-administered rats showed the inhibition of tumor incidence and lipid peroxidation with simultaneous elevation in antioxidants. We suggest that SAC exerts its chemopreventive effects by decreasing lipid peroxidation and enhancing the levels of antioxidants in NDEA carcinogenesis by reducing the formation of free radicals.
Sivapatham Sundaresan; Perumal Subramanian
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Polish journal of pharmacology     Volume:  55     ISSN:  1230-6002     ISO Abbreviation:  Pol J Pharmacol     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2003-07-14     Completed Date:  2004-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313882     Medline TA:  Pol J Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India.
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MeSH Terms
Antioxidants / metabolism*
Carcinogenicity Tests / methods
Cysteine / analogs & derivatives*,  pharmacology*,  therapeutic use
Diethylnitrosamine / toxicity*
Lipid Peroxidation / drug effects*,  physiology
Liver Neoplasms, Experimental / chemically induced,  metabolism*,  prevention & control
Rats, Wistar
Reg. No./Substance:
0/Antioxidants; 21593-77-1/S-allylcysteine; 52-90-4/Cysteine; 55-18-5/Diethylnitrosamine

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