Document Detail

S-adenosylmethionine in treatment of cholestasis after total parenteral nutrition: laboratory investigation and clinical application.
MedLine Citation:
PMID:  14607634     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To observe the effects of S-adenosylmethionine (SAMe) in the treatment of cholestasis after total parenteral nutrition (TPN). METHODS: Thirty SD rats were randomly divided into control group, hypercalorie group, hypercalorie+SAMe group, sepsis group and sepsis+SAMe group to compare their states of cholestasis. Sixteen patients received SAMe because of cholestasis after prolonged TPN, and the therapeutic efficacy was observed. RESULTS: Bile flow was obviously decreased and the serum levels of total bile acid and gamma-glutamyl transpeptidase (gamma-G T) were markedly increased in the hypercalorie and sepsis groups. Meanwhile, hepatocyte fatty degeneration, dilatation of cholangioles, and bile sludge could be seen microscopically. SAMe administration in the hypercalorie+SAMe and sepsis+ SAMe groups could increase the bile flow, decrease the serum levels of total bile acid and gamma-G T, reduce the pathological damage to the liver, and clear the bile sludge in the cholangioles. Cholestasis and abnormal liver function were the main manifestations of the 16 patients before SAMe administration. After SAMe treatment for 3 weeks, serum levels of total bilirubin, alkaline phosphatase (AKP), gamma-G T, alanine amino transferase (ALT), and aspartate amino transferase (AST) were obviously decreased, and normalized in the 4th week. CONCLUSION: SAMe could prevent and treat cholestasis without discontinuation of TPN.
Ning Li; Hong-Hai Zhang; Shao-Hua Wang; Wei-Ming Zhu; Jian-An Ren; Jie-Shou Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepatobiliary & pancreatic diseases international : HBPD INT     Volume:  1     ISSN:  1499-3872     ISO Abbreviation:  HBPD INT     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2003-11-10     Completed Date:  2004-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101151457     Medline TA:  Hepatobiliary Pancreat Dis Int     Country:  China    
Other Details:
Languages:  eng     Pagination:  96-100     Citation Subset:  IM    
Institute of General Surgery, Nanjing General Hospital of Nanjing PLA Command, Nanjing 210002, China.
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MeSH Terms
Bile Acids and Salts / metabolism
Cholestasis / drug therapy*,  etiology*,  metabolism
Disease Models, Animal
Parenteral Nutrition, Total / adverse effects*
Rats, Sprague-Dawley
S-Adenosylmethionine / pharmacology*
Sepsis / drug therapy,  metabolism
Reg. No./Substance:
0/Bile Acids and Salts; 29908-03-0/S-Adenosylmethionine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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