| S-100 protein concentration in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. | |
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MedLine Citation:
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PMID: 9352454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated S-100 levels in paired cerebrospinal fluid (CSF) and serum samples in a group of 135 patients referred to the German Creutzfeldt-Jakob disease (CJD) surveillance unit from June 1993 to May 1995. The patients were seen in a prospective case control study. The diagnosis of probable CJD during life was made in any patient presenting with rapidly progressive dementia of less than 2 years' duration, typical periodic sharp wave complexes (PSWCs) in the EEG and at least two of the following findings: myoclonus, visual/or cerebellar symptoms, pyramidal and/or extrapyramidal signs and/or akinetic mutism. Patients presenting with the above clinical signs and symptoms but without PSWCs were classified as possible, while those with a dementia of a duration exceeding 2 years and without PSWCs were classified as other. S-100 was determined in paired CSF and serum samples by a commercially available enzyme-linked immunosorbent assay. In a group of 76 patients with definite and probable CJD, S-100 concentration (median 25 ng/ml, range 2-117) in CSF was significantly higher (P < 0.0001) than in 32 patients diagnosed as other (median 4 ng/ml, range 1-19). Serum levels of S-100 were below 0.5 ng/ml in all groups. At a cut-off of 8 ng/ml an optimum sensitivity of 84.2% with a specificity of 90.6% for the diagnosis of CJD by the determination of S-100 in CSF is obtained. S-100 levels exceeding 8 ng/ml in CSF support the diagnosis of CJD in any patient presenting with rapidly progressive dementia. |
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Authors:
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M Otto; H Stein; A Szudra; I Zerr; M Bodemer; O Gefeller; S Poser; H A Kretzschmar; M Mäder; T Weber |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurology Volume: 244 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-12-18 Completed Date: 1997-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 566-70 Citation Subset: IM |
Affiliation:
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Neurologische Klinik und Poliklinik, Georg-August-Universität Göttingen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Case-Control Studies Creutzfeldt-Jakob Syndrome / cerebrospinal fluid* Female Humans Male Middle Aged Prospective Studies ROC Curve S100 Proteins / cerebrospinal fluid* |
| Chemical | |
Reg. No./Substance:
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0/S100 Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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