Document Detail

Ryanodine receptor arrays: not just a pretty pattern?
MedLine Citation:
PMID:  18329877     Owner:  NLM     Status:  MEDLINE    
Ryanodine receptors (RyRs) are colossal membrane protein complexes that reside in the endoplasmic reticulum of skeletal and cardiac muscle myocytes and neurons, in addition to many non-excitable cells. They comprise high-conductance ion channels that mediate the massive release of Ca2+ ions from the endoplasmic reticulum into the cytoplasm. This is the trigger for contraction during each muscle excitation-contraction coupling cycle. Individual RyRs are believed to network with other RyRs indirectly, through diffusion of released Ca2+ ions, namely the Ca2+-induced Ca2+ release phenomenon. However, RyRs can intrinsically organize into a regular array resembling a distinctive checkerboard pattern, with each square-shaped receptor appearing to abut four neighbours at each corner. In this opinion article, we describe recent data showing structural interactions between RyR oligomers in reconstituted arrays, and we suggest that this provides strong evidence for direct inter-RyR communication through a novel, allosteric regulatory mechanism.
Chang-Cheng Yin; Leon G D'Cruz; F Anthony Lai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-10
Journal Detail:
Title:  Trends in cell biology     Volume:  18     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-04     Completed Date:  2008-05-27     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  149-56     Citation Subset:  IM    
Department of Biophysics, Peking University Health Science Centre, and Centre for Protein Science, Peking University, Beijing 10083, China.
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MeSH Terms
Allosteric Site
Calcium / metabolism
Models, Biological
Muscle Contraction
Muscle, Skeletal / metabolism
Myocardium / metabolism
Protein Array Analysis / methods*
Ryanodine Receptor Calcium Release Channel / metabolism*
Grant Support
//British Heart Foundation; //Medical Research Council; //Wellcome Trust
Reg. No./Substance:
0/Ions; 0/Ryanodine Receptor Calcium Release Channel; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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