| Rutin Inhibits Oleic Acid Induced Lipid Accumulation via Reducing Lipogenesis and Oxidative Stress in Hepatocarcinoma Cells. | |
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MedLine Citation:
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PMID: 21535797 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Excessive lipid accumulation within liver has been proposed to cause obesity, hyperlipidemia, diabetes, and fatty liver disease. Rutin, a common dietary flavonoid that is consumed in fruits, vegetables, and plant-derived beverages, has various biological functions, including antioxidant, anti-inflammatory, and anticancer effects. However, a hypolipidemic effect of rutin on fatty liver disease has not been reported. In this study, we examined the effect of rutin on reducing lipid accumulation in hepatic cells. Hepatocytes were treated with oleic acid (OA) containing with or without rutin to observe the lipid accumulation by Nile red stain. The result showed rutin suppressed OA-induced lipid accumulation and increased adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) activity in hepatocytes. The expression of critical molecule involved in lipid synthesis, sterol regulatory element binding proteins-1 (SREBP-1), was attenuated in rutin-treated cells. Moreover, long-term incubation of rutin inhibited the transcriptions of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR), glycerol-3-phosphate acyltransferase (GPAT), fatty acid synthase (FAS), and acetyl-coenzyme carboxylase (ACC). Besides, we also found out the antioxidative effect of rutin by increasing the expression of peroxisome proliferator-activated receptor (PPAR)-α and antioxidative enzymes. Taken together, our findings suggest rutin could attenuate lipid accumulation by decreasing lipogenesis and oxidative stress in hepatocyte. |
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Authors:
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Cheng-Hsun Wu; Ming-Cheng Lin; Hsueh-Chun Wang; Mon-Yuan Yang; Ming-Jia Jou; Chau-Jong Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Journal of food science Volume: 76 ISSN: 1750-3841 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0014052 Medline TA: J Food Sci Country: - |
Other Details:
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Languages: ENG Pagination: T65-T72 Citation Subset: - |
Affiliation:
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Authors Wu, Wang, Yang, and Wang are with Inst. of Biochemistry and Biotechnology, Chung Shan Medical Univ., No. 110, Section 1, Chien-kauo N. Rd. Taichung, Taiwan, R.O.C. Author Wu is also with Dept. of Anatomy, China Medical Univ., No. 91, Hsueh-Shih Rd., Taichung 404, Taiwan, R.O.C. Author Lin is with Dept. of Internal Medicine, Chung-Shan Medical Univ., Hospital, No. 110, Section 1, Chien-kauo N. Rd., Taichung, Taiwan, R.O.C. Author Jou is with The School of Chinese Medicine for Post-Baccalaureate College of Medicine, I-Shou Univ., No. 1, Section 1, Syuecheng Rd., Dashu Township, Kaohsiung County 840, R.O.C. Author Wang is with Dept. of Medical Research, Chung Shan Medical Univ. Hospital, No. 110, Section 1, Chien-kauo N. Rd., Taichung, Taiwan, R.O.C. Direct inquiries to author Wang (E-mail: wcj@csmu.edu.tw). |
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