Document Detail


Ruthenium(ii) arene PTA (RAPTA) complexes: impact of enantiomerically pure chiral ligands.
MedLine Citation:
PMID:  23187957     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Organometallic ruthenium(ii) arene complexes containing the PTA ligand ([Ru(η(6)-arene)Cl(2)(PTA)], PTA = 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane, termed RAPTA) show pharmacologically relevant anti-tumour properties in vitro. Two new enantiomeric pairs of RAPTA compounds, containing the chiral arene (R)- or (S)-2-phenyl-N-(1-phenylethylene)acetamide and either dichlorido or oxalato ligands were synthesised and fully characterised. The stability of the complexes towards hydrolysis was assessed and the dichlorido complexes were found to be more stable towards hydrolysis than the prototype complex RAPTA-C, ([Ru(η(6)-p-cymene)Cl(2)(PTA)]). The cytotoxicity of the compounds towards human ovarian cancer cells is moderate to good with a degree of selectivity towards the cancer cells over healthy cells. More significantly, for the first time we were able to establish the influence of a bulky, chiral group attached to the arene on the cytotoxicity of this class of compound, with the S-enantiomer being more cytotoxic than the R-enantiomer.
Authors:
Kelly J Kilpin; Shona M Cammack; Catherine M Clavel; Paul J Dyson
Related Documents :
21619207 - Oxygen sensors based on luminescence quenching of metal complexes:  osmium complexes ...
19202547 - Ferroelectricity and polarity control in solid-state flip-flop supramolecular rotators.
20858597 - Differences in rds trafficking, assembly and function in cones versus rods: insights fr...
16548607 - Spectroscopic and spectroelectrochemical characterization of acceptor--sigma spacer--do...
22009107 - Comparison of ear and chest probes in transcutaneous carbon dioxide pressure measuremen...
21583447 - (3ar,8as,9s,9ar)-9-hydroxy-perhydro-furo[3,2-f]indolizin-6-one.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-28
Journal Detail:
Title:  Dalton transactions (Cambridge, England : 2003)     Volume:  -     ISSN:  1477-9234     ISO Abbreviation:  Dalton Trans     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101176026     Medline TA:  Dalton Trans     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. paul.dyson@epfl.ch.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of soybean protein on novel cardiovascular disease risk factors: a randomized controlled tria...
Next Document:  Damping of the acoustic vibrations of a suspended gold nanowire in air and water environments.