Document Detail

Russell body gastritis in an HIV positive patient: case report and review of literature.
MedLine Citation:
PMID:  22685980     Owner:  NLM     Status:  In-Process    
Russell body gastritis is characterized by accumulation of plasma cells, filled with Russell bodies, in the gastric mucosa. Twelve cases have been reported in the English language medical literature. Its association with Helicobacter pylori gastritis or immunosuppression is known. The present case is the third to be reported in association with HIV infection. An 82-year-old male presented with dyspepsia, loose stools, loss of appetite and weight. Computed tomography scan showed esophageal and gastric wall thickening. Gastrointestinal endoscopy revealed gastritis. Microscopic examination of the biopsy revealed gastric mucosa with diffuse plasma cell infiltration in the lamina propria, associated with large eosinophilic Russell bodies. Immunoperoxidase stains revealed positivity for CD 138 and lambda and kappa chains. Special stain for Helicobacter pylori and immunostain for CD68 were negative. The differential diagnoses include plasmacytoma and mucosa associated lymphoid tissue (MALT) lymphoma with plasmacytic differentiation, which are entities with different prognostic and therapeutic implications.
Amarpreet Bhalla; Diana Mosteanu; Steven Gorelick; Hani-el-Fanek
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Connecticut medicine     Volume:  76     ISSN:  0010-6178     ISO Abbreviation:  Conn Med     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372745     Medline TA:  Conn Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-5     Citation Subset:  IM    
PGY-2 Department of Pathology, Laboratory Medicine, Danbury Hospital.
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