Document Detail

Russell body duodenitis: A histopathological and molecular approach to a rare clinical entity.
MedLine Citation:
PMID:  22673188     Owner:  NLM     Status:  Publisher    
Russell bodies are pink eosinophilic accumulations within plasma cells. To date, two hypotheses have attempted to elucidate the biological events behind the formation of these bodies. One theory sustains that such bodies constitute cytoplasmic accumulation of immunoglobulin derivatives contained in the perinuclear cistern of the smooth endoplasmic reticulum because of an increased synthesis or altered secretion. On the other hand, since its initial description in the medical literature, several authors have attributed the formation of such bodies to the presence of microorganisms such as in the case of Russell body gastritis and its association to Helicobacter pylori infection. In an attempt to possibly characterize the presence of an infectious organism, we performed a thorough biomolecular analysis on a case of a 69-year-old female presenting with Russell body duodenitis which, to the best of our knowledge, constitutes the second report of this clinical entity in the English literature. In light that the events behind formation of such bodies in H. pylori-negative individuals remain unclear, we hypothesize on the possible pathways that could have led to their reactive mechanical and immune derivation.
Alberto Paniz Mondolfi; Maria Samuel; Judith Kikhney; Annette Moter; David Feldman; Denisa Slova; Alexander Filatov; Neil Theise
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-4
Journal Detail:
Title:  Pathology, research and practice     Volume:  -     ISSN:  1618-0631     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier GmbH. All rights reserved.
Department of Pathology and Laboratory Medicine, St. Luke's-Roosevelt Hospital Center (Columbia University College of Physicians and Surgeons), New York, NY 10025, USA; Department of Pathology and Laboratory Medicine, Beth Israel Medical Center (Manhattan Campus for the Albert Einstein College of Medicine), New York, NY 10003, USA; Laboratorio de Bioquímica, Instituto de Biomedicina, UCV/MSDS/IVSS, Caracas 1010, Venezuela.
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