| Rupture of ovarian follicles at ovulation. | |
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MedLine Citation:
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PMID: 171404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The appearance of mammalian follicles at the time of ovulation has been described by numerous observers. Importance features to which attention has been directed are: changes in the vascularization of the follicle, the appearance of an avascular area known as the macula pellucida or stigma, the formation of small blood clots near the stigma and some extravasation of blood, and the rupture of the follicle at the stigma and exist of the oocyte and follicular fluid. The first major advance beyond this descriptive stage came with the demonstration that antral pressure does not increase prior to follicle rupture. This observation eliminated a number of hypotheses concerning ovulation and focused attention on the deterioration and weakening of the follicle wall at the stigma. That the follicle wall weakness prior to rupture is established beyond doubt by gross observations of its increased fragility during various manipulative procedures, by stress-strain measurements in vivo and in vitro, and by histological observations. Progressive weakening of the stigma region by thinning and degeneration is a fundamental aspect of the preovulatory maturation of follicles, and it would appear to be a necessary prerequisite to rupture. |
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Authors:
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E L Parr |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of reproduction and fertility. Supplement Volume: - ISSN: 0449-3087 ISO Abbreviation: J. Reprod. Fertil. Suppl. Publication Date: 1975 Apr |
Date Detail:
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Created Date: 1976-01-17 Completed Date: 1976-01-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0225652 Medline TA: J Reprod Fertil Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / pharmacology Chorionic Gonadotropin / physiology Collagen / physiology Connective Tissue / enzymology Female Granulosa Cells / cytology Hydrostatic Pressure Indomethacin / pharmacology Mice Microbial Collagenase / analysis Ovarian Follicle / anatomy & histology, drug effects, physiology* Ovulation* Peptide Hydrolases / analysis Prostaglandins / pharmacology Rabbits Rats Theca Cells / cytology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Chorionic Gonadotropin; 0/Prostaglandins; 53-86-1/Indomethacin; 9007-34-5/Collagen; EC 3.4.-/Peptide Hydrolases; EC 3.4.24.3/Microbial Collagenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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