Document Detail

Rupture of chordae tendineae in patients with beta-thalassemia.
MedLine Citation:
PMID:  15089770     Owner:  NLM     Status:  MEDLINE    
Cardiac disease is the primary cause of mortality in beta-thalassemia patients. Except for ventricular dysfunction and pulmonary hypertension that represent the main forms of heart disease in these patients, valvular abnormalities including valvular regurgitation, endocardial thickening and calcification and mitral valve prolapse have also been described. Here we present two patients with thalassemia major and mitral chordal rupture, a previously undescribed abnormality in this population. Pathogenesis of this finding may involve thalassemia-related pseudoxanthoma elasticum-like syndrome, a diffuse elastic tissue defect, which is observed with a notable frequency in these patients and has been associated with numerous cardiovascular complications, including valvular ones.
Dimitrios Farmakis; Spyros Deftereos; Anastasios Giakoumis; Evangelos Polymeropoulos; Athanasios Aessopos
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of haematology     Volume:  72     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-05-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  296-8     Citation Subset:  IM    
First Department of Internal Medicine, University of Athens Medical School, "Laiko" General Hospital, Athens, Greece.
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MeSH Terms
Calcinosis / etiology,  ultrasonography
Chordae Tendineae / pathology*,  ultrasonography
Elastic Tissue / pathology
Heart Diseases / etiology*,  ultrasonography
Mitral Valve Insufficiency / etiology*,  ultrasonography
Rupture, Spontaneous
beta-Thalassemia / complications*

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