Document Detail


Runx3 controls growth and differentiation of gastric epithelial cells in mammals.
MedLine Citation:
PMID:  16466388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Runx3 is a transcription factor expressed by gastric epithelial cells. In the Runx3(-/-) mouse, gastric epithelia exhibited hyperplasia, and epithelial apoptosis was suppressed. By analyzing growth of the epithelial cells in primary culture, we found that Runx3(-/-) gastric epithelial cells are less sensitive to the growth-inhibitory and apoptosis-inducing activities of TGF-beta, suggesting that Runx3 is a major growth regulator of gastric epithelial cells by regulating their response to TGF-beta. We also found that Runx3 plays an important role in the control of gastric epithelial differentiation. When subcutaneously implanted into nude mice, Runx3(-/-) gastric epithelial cells formed tumors in which some cells differentiated into intestinal-type cells. Clonal analysis showed that gastric epithelial cells transdifferentiate into intestinal-type cells in the tumor. Considering that gastric epithelial differentiation is very stable, and that intestinal-type cells never differentiate in the mouse stomach, it is remarkable that gastric epithelial cells transdifferentiate into intestinal-type cells. We conclude that Runx3 is deeply involved in the control of both growth and differentiation of gastric epithelial cells. The role of Runx3 in the specification of gastric epithelial cells is discussed.
Authors:
Hiroshi Fukamachi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Development, growth & differentiation     Volume:  48     ISSN:  0012-1592     ISO Abbreviation:  Dev. Growth Differ.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-09     Completed Date:  2006-05-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0356504     Medline TA:  Dev Growth Differ     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1-13     Citation Subset:  IM    
Affiliation:
Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Tokyo 113-8519, Japan. hfukama.monc@tmd.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Cell Differentiation / genetics
Core Binding Factor Alpha 3 Subunit / genetics,  physiology*
Gastric Mucosa / cytology*,  drug effects,  growth & development*
Intestinal Mucosa / cytology
Mice
Stomach Neoplasms / genetics,  metabolism,  pathology
Transforming Growth Factor beta / pharmacology
Chemical
Reg. No./Substance:
0/Core Binding Factor Alpha 3 Subunit; 0/Runx3 protein, mouse; 0/Transforming Growth Factor beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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