Document Detail


Running-induced epigenetic and gene expression changes in the adolescent brain.
MedLine Citation:
PMID:  23178748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Physical exercise is associated with positive neural functioning. Here we examined the gene expression consequences of 1 week of voluntary wheel running in adolescent male mice. We assayed expression levels of genes associated with synaptic plasticity, signaling pathways, and epigenetic modifying enzymes. Two regions were examined: the hippocampus, which is typically examined in exercise studies, and the cerebellum, an area directly involved in motor control and learning. After 1 week of exercise, global acetylation of histone 3 was increased in both brain regions. Interestingly this was correlated with increased brain derived neural growth factor in the hippocampus, as noted in many other studies, but only a trend was found in cerebellum. Differences and similarities between the two areas were noted for genes encoding functional proteins. In contrast, the expression pattern of DNA methyltransferases (Dnmts) and histone deacetylases (Hdacs), genes that influence DNA methylation and histone modifications in general, decreased in both regions with exercise. We hypothesize that epigenetic mechanisms, involving many of the genes assessed here, are essential for the positive affects of exercise on behavior and suspect these data have relevance for adolescent boys.
Authors:
Jean LeBeau Abel; Emilie F Rissman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-23
Journal Detail:
Title:  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience     Volume:  31     ISSN:  1873-474X     ISO Abbreviation:  Int. J. Dev. Neurosci.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-07-05     Completed Date:  2014-02-14     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8401784     Medline TA:  Int J Dev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  382-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 ISDN. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Brain / physiology*
Epigenesis, Genetic / physiology*
Epigenomics*
Gene Expression / physiology*
Histones
Mice
Mice, Inbred C57BL
Nerve Tissue Proteins / metabolism
Neuronal Plasticity / physiology
Physical Conditioning, Animal*
Signal Transduction / physiology
Grant Support
ID/Acronym/Agency:
P30 CA044579/CA/NCI NIH HHS; R01 MH057759/MH/NIMH NIH HHS; R01 MH057759/MH/NIMH NIH HHS; R21 NS079316/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Histones; 0/Nerve Tissue Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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