| Running-induced epigenetic and gene expression changes in the adolescent brain. | |
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MedLine Citation:
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PMID: 23178748 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Physical exercise is associated with positive neural functioning. Here we examined the gene expression consequences of one week of voluntary wheel running in adolescent male mice. We assayed expression levels of genes associated with synaptic plasticity, signaling pathways, and epigenetic modifying enzymes. Two regions were examined: the hippocampus, which is typically examined in exercise studies, and the cerebellum, an area directly involved in motor control and learning. After one week of exercise, global acetylation of histone 3 was increased in both brain regions. Interestingly this was correlated with increased brain derived neural growth factor in the hippocampus, as noted in many other studies, but only a trend was found in cerebellum. Differences and similarities between the two areas were noted for genes encoding functional proteins. In contrast, the expression pattern of DNA methyltransferases (Dnmts) and histone deacetylases (Hdacs), genes that influence DNA methylation and histone modifications in general, decreased in both regions with exercise. We hypothesize that epigenetic mechanisms, involving many of the genes assessed here, are essential for the positive affects of exercise on behavior and suspect these data have relevance for adolescent boys. |
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Authors:
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Jean Lebeau Abel; Emilie F Rissman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-22 |
Journal Detail:
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Title: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience Volume: - ISSN: 1873-474X ISO Abbreviation: Int. J. Dev. Neurosci. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8401784 Medline TA: Int J Dev Neurosci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 ISDN. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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