Document Detail


Running exercise for short duration increases bone mineral density of loaded long bones in young growing rats.
MedLine Citation:
PMID:  19776531     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Running exercise is an effective therapy for the prevention of osteoporosis; however, appropriate duration of exercise has not been determined. We therefore investigated the effect of exercise duration on bone mineral density (BMD) and systemic bone metabolism using young growing rats. Fifteen 8-week-old female Wistar rats were divided into three groups according to running load: control group (no running), short duration (30 min/day) and long duration (180 min/day), and animals ran on a treadmill 5 days per week over an 8-week period. BMD of the tibia was measured using peripheral quantitative computed tomography, and serum levels of tartarate-resistant acid phosphatase (TRAP), a bone resorption marker and alkaline phosphatase (ALP), a bone formation marker were measured to know whether the treadmill exercise would affect systemic bone metabolism. Short-duration running exercise (30 min/day) caused a significant increase in BMD of the metaphyseal trabecula (p < 0.05) with a reduction of serum TRAP levels (p < 0.01) and an increase in serum levels of calcium (p < 0.05) and phosphorus (p < 0.01). Conversely, long-duration exercise (180 min/day) significantly reduced BMD of the diaphyseal and metaphyseal cortex and that of the diaphyseal trabecula with a significant reduction of serum ALP levels and a significant increase in serum phosphorus. These findings suggest that short-duration exercise may increase BMD through suppression of bone resorption, whereas long-duration exercise may reduce BMD through suppression of bone formation. Exercising for short duration but not prolonged exercise is recommended to increase BMD of loaded long bones.
Authors:
Yoshinobu Hagihara; Arata Nakajima; Satoshi Fukuda; Sumio Goto; Haruzo Iida; Masashi Yamazaki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  219     ISSN:  1349-3329     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-24     Completed Date:  2009-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  IM    
Affiliation:
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acid Phosphatase / blood
Alkaline Phosphatase / blood
Animals
Body Weight / physiology
Bone Density / physiology*
Calcium / blood
Female
Isoenzymes / blood
Phosphorus / blood
Physical Conditioning, Animal*
Rats
Rats, Wistar
Tibia / growth & development*,  physiology*
Time Factors
Weight Gain / physiology
Weight-Bearing / physiology*
Chemical
Reg. No./Substance:
0/Isoenzymes; 7440-70-2/Calcium; 7723-14-0/Phosphorus; EC 3.1.3.-/tartrate-resistant acid phosphatase; EC 3.1.3.1/Alkaline Phosphatase; EC 3.1.3.2/Acid Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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