| Running exercise increases tumor necrosis factor-alpha secreting from mesenteric fat in insulin-resistant rats. | |
MedLine Citation:
|
PMID: 10447208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obese subjects, through its overexpression in fat tissue. However, how exercise can modify the expression of TNF-alpha is controversial. We examined TNF-alpha in adipose tissue using an animal model of insulin resistance that was produced by feeding rats a diet high in sucrose. The rats were allocated to one of three groups: those receiving a starch-based diet (control group): those fed a high-sucrose diet (sucrose-fed group): and those fed a high-sucrose diet and given wheel exercise (exercised group). The animals were allowed to eat and drink ad lib for 4 or 12 weeks (4 wk: control n=7, sucrose-fed n=7, exercised n=10; 12 wk: control n=5, sucrose-fed n=5, exercised n=9). The voluntary wheel exercise was initiated with the feeding of the high-sucrose diet. The rats in the exercise groups ran 15 +/- 3 km/week. We showed that 12-week voluntary running exercise significantly (P<0.05) increased both TNF-alpha protein (5-fold) and mRNA (1.4 fold) in the mesenteric fat of insulin-resistant rats compared to non-exercised sucrose-fed mice. Accordingly, in exercised group, plasma glucose (124 +/- 9 mEq/L vs 141 +/- 11 mEq/L). and free fatty acid (0.98 +/- 0.07 mEq/L vs 1.4 +/- 0.05 mEq/L) concentrating in portal vein blood were reduced compared to sucrose-fed group. The amounts of fatty tissue both in mesenteric and subcutaneous tissues were significantly (P<0.05) decreased through running exercise. We consider that up-regulation of TNF-alpha in mesenteric fat may be a compensatory mechanism for the reduction of fatty acid in adipose tissues and this change could control metabolic homeostasis during exercise to modulate a hyperinsulinemic state. |
Authors:
|
M Nara; T Kanda; S Tsukui; T Inukai; Y Shimomura; S Inoue; I Kobayashi |
Related Documents
:
|
3260588 - Influence of exercise on the immune function of rats of various ages. 15845588 - Age is no barrier to muscle structural, biochemical and angiogenic adaptations to train... 3410628 - Endurance exercise alters the morphology of fast- and slow-twitch rat neuromuscular jun... 18991868 - Influence of chronic exercise on the amphetamine-induced dopamine release and neurodege... 24589558 - Simple score versus standard exercise test for the prediction of coronary artery diseas... 2262228 - Changes in selected blood measures during repeated days of intense training and carbohy... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Life sciences Volume: 65 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1999 |
Date Detail:
|
Created Date: 1999-08-27 Completed Date: 1999-08-27 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 237-44 Citation Subset: IM |
Affiliation:
|
Department of Laboratory Medicine, Gunma University School of Medicine, Maebashi, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
metabolism* Animals Blood Glucose / metabolism Body Weight Dietary Sucrose / metabolism Energy Intake Glucose / metabolism Insulin Resistance* Male Mesentery / metabolism Mice Physical Exertion / physiology* RNA, Messenger / metabolism Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Dietary Sucrose; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Calculation of relative binding free energy difference of DHFR inhibitors by a finite difference the...
Next Document: Production of lysophosphatidic acid by lysophospholipase D in incubated plasma of spontaneously hype...