Document Detail

Running and addiction: precipitated withdrawal in a rat model of activity-based anorexia.
MedLine Citation:
PMID:  19634951     Owner:  NLM     Status:  MEDLINE    
Exercise improves cardiovascular health, strengthens muscles and bones, stimulates neuroplasticity, and promotes feelings of well-being. However, when taken to extremes, exercise can develop into an addictive-like behavior. To assess the addictive potential of exercise, withdrawal symptoms following injections of 1.0 mg/kg naloxone were compared in active and inactive male and female rats. Active and inactive rats were given food for 1 hr or 24 hr/day. Additionally, a group of inactive rats was pair-fed the amount of food consumed on the previous day by food-restricted active rats. Rats fed for 1 hr/day decreased food intake and lost weight. Additionally, food-restricted active rats increased wheel running. There was a direct relationship between the intensity of running and the severity of withdrawal symptoms. Active food-restricted rats displayed the most withdrawal symptoms, followed by active rats given 24-hr access to food. Only minimal withdrawal symptoms were observed in inactive rats. These findings support the hypothesis that exercise-induced increases in endogenous opioid peptides act in a manner similar to chronic administration of opiate drugs.
Robin B Kanarek; Kristen E D'Anci; Nicole Jurdak; Wendy Foulds Mathes
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  123     ISSN:  1939-0084     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-28     Completed Date:  2009-11-06     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  905-12     Citation Subset:  IM    
Copyright Information:
2009 APA, all rights reserved
Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA.
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MeSH Terms
Analysis of Variance
Anorexia / physiopathology*
Body Weight / drug effects
Disease Models, Animal
Feeding Behavior / drug effects,  physiology
Motor Activity / drug effects,  physiology
Naloxone / administration & dosage,  pharmacology*
Narcotic Antagonists / administration & dosage,  pharmacology*
Physical Conditioning, Animal*
Rats, Long-Evans
Sex Characteristics
Substance Withdrawal Syndrome / physiopathology*
Grant Support
R01 DA004132-08/DA/NIDA NIH HHS; R01-DA004132/DA/NIDA NIH HHS
Reg. No./Substance:
0/Narcotic Antagonists; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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