| Running and addiction: precipitated withdrawal in a rat model of activity-based anorexia. | |
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MedLine Citation:
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PMID: 19634951 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise improves cardiovascular health, strengthens muscles and bones, stimulates neuroplasticity, and promotes feelings of well-being. However, when taken to extremes, exercise can develop into an addictive-like behavior. To assess the addictive potential of exercise, withdrawal symptoms following injections of 1.0 mg/kg naloxone were compared in active and inactive male and female rats. Active and inactive rats were given food for 1 hr or 24 hr/day. Additionally, a group of inactive rats was pair-fed the amount of food consumed on the previous day by food-restricted active rats. Rats fed for 1 hr/day decreased food intake and lost weight. Additionally, food-restricted active rats increased wheel running. There was a direct relationship between the intensity of running and the severity of withdrawal symptoms. Active food-restricted rats displayed the most withdrawal symptoms, followed by active rats given 24-hr access to food. Only minimal withdrawal symptoms were observed in inactive rats. These findings support the hypothesis that exercise-induced increases in endogenous opioid peptides act in a manner similar to chronic administration of opiate drugs. |
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Authors:
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Robin B Kanarek; Kristen E D'Anci; Nicole Jurdak; Wendy Foulds Mathes |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Behavioral neuroscience Volume: 123 ISSN: 1939-0084 ISO Abbreviation: Behav. Neurosci. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-28 Completed Date: 2009-11-06 Revised Date: 2010-09-24 |
Medline Journal Info:
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Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 905-12 Citation Subset: IM |
Copyright Information:
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2009 APA, all rights reserved |
Affiliation:
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Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA. Robin.kanarek@tufts.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Anorexia / physiopathology* Body Weight / drug effects Disease Models, Animal Feeding Behavior / drug effects, physiology Female Male Motor Activity / drug effects, physiology Naloxone / administration & dosage, pharmacology* Narcotic Antagonists / administration & dosage, pharmacology* Physical Conditioning, Animal* Rats Rats, Long-Evans Sex Characteristics Substance Withdrawal Syndrome / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DA004132-08/DA/NIDA NIH HHS; R01-DA004132/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Narcotic Antagonists; 465-65-6/Naloxone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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