Document Detail

Run-up to participation in ATACH II in Japan.
MedLine Citation:
PMID:  23230457     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Intracerebral hemorrhage (ICH) is a major cause of morbidity and mortality in Japan. Seventeen Japanese institutions are participating in the Antihypertensive Treatment for Acute Cerebral Hemorrhage (ATACH) II Trial ( no. NCT01176565; UMIN 000006526). This phase III trial is designed to determine the therapeutic benefit of early intensive systolic blood pressure (BP) lowering for acute hypertension in ICH patients. This report explains the long run-up to reach the start of patient registration in ATACH II in Japan, including our preliminary study, a nationwide survey on antihypertensive treatment for acute ICH patients, a multicenter study for hyperacute BP lowering (the SAMURAI-ICH study), revision of the official Japanese label for intravenous nicardipine, and construction of the infrastructure for the trial.
K Toyoda; S Sato; M Koga; H Yamamoto; J Nakagawara; E Furui; Y Shiokawa; Y Hasegawa; S Okuda; N Sakai; K Kimura; Y Okada; S Yoshimura; H Hoshino; Y Uesaka; T Nakashima; Y Itoh; T Ueda; T Nishi; J Gotoh; K Nagatsuka; S Arihiro; T Yamaguchi; K Minematsu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of vascular and interventional neurology     Volume:  5     ISSN:  1941-5893     ISO Abbreviation:  J Vasc Interv Neurol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-07-04     Revised Date:  2013-07-05    
Medline Journal Info:
Nlm Unique ID:  101511381     Medline TA:  J Vasc Interv Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  -    
Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita 565-8565, Japan.
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