Document Detail

Ruling out myocardial infarction with troponin T and creatine kinase MB mass: diagnostic and prognostic aspects.
MedLine Citation:
PMID:  11771820     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the time window for ruling out myocardial infarction (MI) with troponin T (TnT) and creatine kinase isoenzyme MB mass (CK-MBm) and the prognosis of patients with ruled-out MI diagnosis. DESIGN: The study was based on 397 patients admitted with a suspected acute coronary syndrome but with relief of symptoms within 24 h. RESULTS: MI diagnosis was confirmed with elevated TnT (>0.10 microg/l) in 108 patients. in 91% within 12-24 h from the onset of symptoms, and in 99% within 12 h from admission. In 94 of these patients CK-MBm became elevated (>5.0 microg/l). in 95% within 10-12 h from the onset of symptoms, and in 99% within 6 h from admission. Among patients with ruled-out MI diagnosis, the 1-year incidence of recurrent coronary events was 29% in those with positive history of coronary heart disease (CHD) but only 7% in those without prior CHD (p < 0.001). CONCLUSION: Using TnT or CK-MBm, MI can be ruled out within 12 h from admission in the majority of patients. Among patients with ruled-out MI diagnosis, positive history of CHD is an important determinant of prognosis.
H Koukkunen; K Penttilä; A Kemppainen; I Penttilä; M Halinen; T Rantanen; K Pyörälä
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  35     ISSN:  1401-7431     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-12-28     Completed Date:  2002-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  302-6     Citation Subset:  IM    
Department of Medicine, Kuopio University Hospital, Finland.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Coronary Disease / diagnosis
Creatine Kinase / blood*
Creatine Kinase, MB Form
Diagnosis, Differential
Isoenzymes / blood*
Middle Aged
Myocardial Infarction / blood,  diagnosis*
Sensitivity and Specificity
Troponin T / blood*
Reg. No./Substance:
0/Biological Markers; 0/Isoenzymes; 0/Troponin T; EC Kinase; EC Kinase, MB Form

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