| Ruling out myocardial infarction with troponin T and creatine kinase MB mass: diagnostic and prognostic aspects. | |
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MedLine Citation:
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PMID: 11771820 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the time window for ruling out myocardial infarction (MI) with troponin T (TnT) and creatine kinase isoenzyme MB mass (CK-MBm) and the prognosis of patients with ruled-out MI diagnosis. DESIGN: The study was based on 397 patients admitted with a suspected acute coronary syndrome but with relief of symptoms within 24 h. RESULTS: MI diagnosis was confirmed with elevated TnT (>0.10 microg/l) in 108 patients. in 91% within 12-24 h from the onset of symptoms, and in 99% within 12 h from admission. In 94 of these patients CK-MBm became elevated (>5.0 microg/l). in 95% within 10-12 h from the onset of symptoms, and in 99% within 6 h from admission. Among patients with ruled-out MI diagnosis, the 1-year incidence of recurrent coronary events was 29% in those with positive history of coronary heart disease (CHD) but only 7% in those without prior CHD (p < 0.001). CONCLUSION: Using TnT or CK-MBm, MI can be ruled out within 12 h from admission in the majority of patients. Among patients with ruled-out MI diagnosis, positive history of CHD is an important determinant of prognosis. |
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Authors:
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H Koukkunen; K Penttilä; A Kemppainen; I Penttilä; M Halinen; T Rantanen; K Pyörälä |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 35 ISSN: 1401-7431 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-12-28 Completed Date: 2002-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: Norway |
Other Details:
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Languages: eng Pagination: 302-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Kuopio University Hospital, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Biological Markers / blood Coronary Disease / diagnosis Creatine Kinase / blood* Creatine Kinase, MB Form Diagnosis, Differential Female Humans Isoenzymes / blood* Male Middle Aged Myocardial Infarction / blood, diagnosis* Prognosis Sensitivity and Specificity Troponin T / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Isoenzymes; 0/Troponin T; EC 2.7.3.2/Creatine Kinase; EC 2.7.3.2/Creatine Kinase, MB Form |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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