Document Detail

Rufinamide for refractory focal seizures: an open-label, multicenter European study.
MedLine Citation:
PMID:  23079159     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The present study aimed to assess the efficacy and tolerability of rufinamide as adjunctive drug for the treatment of a large series of children, adolescents and adults with refractory cryptogenic or symptomatic focal epilepsy.
METHODS: Patients were recruited in a prospective, add-on, open-label treatment study from six Italian and one German centers for pediatric and adolescent epilepsy care. Inclusion criteria were: (1) age 3 years or more; (2) diagnosis of cryptogenic or symptomatic focal epilepsy refractory to at least three previous antiepileptic drugs (AEDs), alone or in combination; (3) more than one seizure per month in the last 6 months; (4) use of at least one other AED, but no more than three, at baseline; (5) informed consent from parents and/or caregivers.
RESULTS: Sixty-eight patients (40 males, 28 females), aged between 3 and 63 years (mean 19.9 years, median 16.0)±SD 12.58, with cryptogenic (28 pts, 41.2%) or symptomatic focal epilepsy (40 pts, 58.8%), were recruited in the study. After a mean follow-up period of 10.4±10.29 months, twenty-two patients (32.3%) had a 50-99% seizure reduction, and none became seizure-free. Twelve patients (17.6%) had a 25-49% seizure decrease, while in 30 (44.1%) seizure frequency was unchanged. A seizure worsening was reported in 5 patients (7.3%). A better response to rufinamide occurred in frontal lobe seizures (51.6%) and secondary generalized tonic-clonic seizures (50%).
CONCLUSION: Rufinamide was effective against focal-onset seizures, particularly in the treatment of secondary generalized frontal lobe seizures.
Giangennaro Coppola; Nelia Zamponi; Gerhard Kluger; Arndt Mueller; Mazzotta Anna Rita; Pasquale Parisi; Claudia Isone; Elena Santoro; Paolo Curatolo; Alberto Verrotti
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2012-10-16
Journal Detail:
Title:  Seizure     Volume:  22     ISSN:  1532-2688     ISO Abbreviation:  Seizure     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-07-01     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  33-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Anticonvulsants / blood,  therapeutic use*
Child, Preschool
Drug Therapy, Combination
Longitudinal Studies
Middle Aged
Seizures / blood,  drug therapy*
Treatment Outcome
Triazoles / blood,  therapeutic use*
Young Adult
Reg. No./Substance:
0/Anticonvulsants; 0/Triazoles; 106308-44-5/rufinamide

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