| Rufinamide: a new antiepileptic drug treatment for Lennox-Gastaut syndrome. | |
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MedLine Citation:
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PMID: 20518600 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lennox-Gastaut syndrome is a relatively rare epilepsy syndrome that usually begins in early-mid childhood and is characterized by multiple seizure types, particularly generalized seizures, which are often resistant to antiepileptic drug medication. Rufinamide is a new antiepileptic drug approved as adjunctive therapy to treat seizures in Lennox-Gastaut syndrome in those 4 years of age and older. In this article, the putative mechanism of action is described, along with data relating to its pharmacokinetics and metabolism. Key findings from clinical trials are presented and discussed. Adverse effects are summarized and compared with those encountered with competitor antiepileptic drugs. Finally, the role of rufinamide in the holistic management of subjects with Lennox-Gastaut syndrome is considered. |
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Authors:
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Colin D Ferrie |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert review of neurotherapeutics Volume: 10 ISSN: 1744-8360 ISO Abbreviation: Expert Rev Neurother Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-03 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101129944 Medline TA: Expert Rev Neurother Country: England |
Other Details:
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Languages: eng Pagination: 851-60 Citation Subset: IM |
Affiliation:
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Department of Paediatric Neurology, Paediatric Offices, Old Main Site (Block 16), A Floor, Leeds General Infirmary, Leeds, LS1 3EX, UK. colin.ferrie@leedsth.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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adverse effects,
pharmacology,
therapeutic use Child Clinical Trials as Topic Epilepsy, Generalized / drug therapy* Humans Syndrome Triazoles / adverse effects, pharmacology*, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Triazoles; 106308-44-5/rufinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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