| Rufinamide in refractory childhood epileptic encephalopathies other than Lennox-Gastaut syndrome. | |
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MedLine Citation:
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PMID: 20666837 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: To report on the first multicenter Italian experience with rufinamide as adjunctive drug in children, adolescents and young adults with refractory childhood-onset epileptic encephalopathies other than Lennox-Gastaut syndrome. METHODS: Thirty-eight patients (19 males, 19 females), aged between 4 and 34 (mean 13.7 ± 8.3, median 12.5), all affected by different types of childhood-onset refractory epileptic encephalopathies other than Lennox-Gastaut syndrome, were treated with rufinamide as adjunctive drug for a mean period of 11.4 months (range 3-26 months). RESULTS: Fifteen of 38 patients (39.5%) had a ≥ 50% seizure reduction in countable seizures. Complete seizure freedom was achieved in one of these patients (2.6%). Three patients (7.9%) had a 25-49% seizure reduction, whilst seizure frequency remained unchanged in 15 (39.5%) and increased in five patients (13.1%). Eleven patients (28.9%) reported adverse side effects. Vomiting was reported in five patients (13.1%); drowsiness, decreased appetite and irritability with migraine manifested in other four patients. They were transient and mild in all cases. CONCLUSION: Rufinamide may be an effective and well-tolerated adjunctive drug for the treatment of refractory childhood-onset epileptic encephalopathies other than Lennox-Gastaut syndrome. Rufinamide was most effective in patients with drop-attacks and (bi)frontal spike-wave discharges. |
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Authors:
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G Coppola; S Grosso; E Franzoni; P Veggiotti; N Zamponi; P Parisi; A Spalice; F Habetswallner; A Fels; A Verrotti; A D'Aniello; S Mangano; A Balestri; P Curatolo; A Pascotto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 18 ISSN: 1468-1331 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 246-51 Citation Subset: IM |
Copyright Information:
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© 2010 The Author(s). European Journal of Neurology © 2010 EFNS. |
Affiliation:
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Clinic of Child Neuropsychiatry, Second University of Naples, Naples, Italy. giangennaro.coppola@unina2.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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