Document Detail

Rudiments of subgroup analyses.
MedLine Citation:
PMID:  22226001     Owner:  NLM     Status:  MEDLINE    
Subgroup analysis in a clinical trial is the evaluation of the effect of a randomly allocated intervention within only a fraction of the patients in the entire research cohort. This article provides several examples of the use of subgroup analysis, discusses some of the interpretative difficulties that occur during the assessment of the effect of therapy within subgroups, and provides a summary of recent recommendations on reporting subgroup analyses in the literature. Although subgroup analyses can provide new, provocative, and sometimes clinically relevant findings, this group of evaluations must be handled with extreme care.
Lemuel A Moyé
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  54     ISSN:  1873-1740     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2012-01-09     Completed Date:  2012-02-23     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  338-42     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
University of Texas School of Public Health-Houston, Houston, TX, USA.
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MeSH Terms
Cardiovascular Diseases / therapy
Cohort Studies
Data Interpretation, Statistical*
Practice Guidelines as Topic
Prospective Studies
Randomized Controlled Trials as Topic / standards*
Research Design / standards*
Sample Size

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