Document Detail

Rubella seroprevalence in an unvaccinated pregnant population in Malatya, Turkey.
MedLine Citation:
PMID:  17222875     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Controlling congenital rubella by 2010 is one of the targets of the World Health Organization. Most European countries currently include rubella vaccine in their national immunization programmes, but not yet in Turkey. OBJECTIVES: To define rubella seroprevalence in pregnancy in Malatya, Turkey. STUDY DESIGN: A cross-sectional interview survey was conducted among pregnant women living in Malatya province from November 2003 to May 2004, together with a follow-up component. METHODS: Stratified probability proportional to size sampling methodology. A total of 824 pregnant women from 60 clusters were enrolled. After obtaining informed consent, participants' socio-demographic and fertility characteristics were collected by interview questionnaire. Various blood samples were drawn. After storing serum samples at -20 degrees C for 6 months, anti-rubella IgM and IgG titres were studied by micro ELISA. Only 803 sera were eligible for serological study. RESULTS: Of the 803 samples tested for rubella antibodies, 753 cases (93.8%) had anti-rubella IgG positivity, indicating past infection. Five of the pregnant women (0.6%) had both anti-rubella IgM and IgG positive results, suggesting a recent infection. The remaining 45 women (5.6%) were seronegative for both antibodies. Seroprevalence was not associated with age or urban/rural residency. All the five anti-rubella IgM positive women were in the second trimester of pregnancy. CONCLUSIONS: As 5.6% of pregnant women were susceptible to rubella during pregnancy, and five of them had already had a recent infection, immunization efforts should be directed at babies and adolescents.
E Pehlivan; L Karaoglu; M Ozen; G Gunes; M S Tekerekoglu; M F Genc; M Egri; C Ercan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-12
Journal Detail:
Title:  Public health     Volume:  121     ISSN:  0033-3506     ISO Abbreviation:  Public Health     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376507     Medline TA:  Public Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  462-8     Citation Subset:  IM    
Department of Public Health, Inonu University, Malatya, Turkey.
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MeSH Terms
Cross-Sectional Studies
Middle Aged
Pregnancy Complications, Infectious / epidemiology*
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Reproductive History
Rubella / epidemiology*
Seroepidemiologic Studies
Socioeconomic Factors
Turkey / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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