| Roxithromycin in prevention of acute coronary syndrome associated with Chlamydia pneumoniae infection: a randomized placebo controlled trial. | |
| | |
MedLine Citation:
|
PMID: 12002908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The role of Chlamydia pneumoniae infection in precipitating acute coronary syndrome (ACS) is unclear. Some studies have indicated that intervention with macrolide antibiotics might reduce coronary events in patients with ACS. A double blind, randomized, placebo-control trial was conducted on 84 ACS patients. Patients were randomized to 30 days of treatment with roxithromycin (150 mg, twice daily) or matching placebo. The follow-up period was 90 days, and the primary clinical end point included cardiovascular death, unplanned revascularization and recurrent angina/MI. Anti-C. pneumoniae IgG positive in 24 of 43 (55.8%) patients in the roxithromycin group and 23 of 41 (56.1%) patients in the placebo group. Anti-C. pneumoniae IgA positive in 20 of 43 (46.5%) patients in the roxithromycin group and 13 of 41 (31.7%) patients in the placebo group. Thirty-three cardiac events occurred (2 cardiovascular deaths, 9 CABG, 12 PTCA and 10 recurrent angina/MI) with 17 events in the roxithromycin group and 16 events in the placebo group. There was no significant difference of cardiac events between the roxithromycin and placebo groups. The present study suggests that antibiotic therapy with roxithromycin is not associated with reduction of cardiac events as reported by other investigators. However, therapeutic interventions may need to be specifically targeted to a group of patients who are confirmed with chronic C. pneumoniae infection. |
| | |
Authors:
|
W Leowattana; K Bhuripanyo; L Singhaviranon; S Akaniroj; N Mahanonda; M Samranthin; S Pokum |
Related Documents
:
|
20412178 - Prevention of travelers' diarrhea with rifaximin in us travelers to mexico. 10873968 - Effect of a three month course of ciprofloxacin on the outcome of reactive arthritis. 15106168 - Antibiotics for community acquired pneumonia in adult outpatients. 8351118 - Comparative trial of fluconazole and amphotericin in the treatment of denture stomatitis. 2570798 - Prolongation of simple and choice reaction times in a double-blind comparison of twice-... 10337978 - Intratympanic gentamicin titration therapy for intractable meniere's disease. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the Medical Association of Thailand = Chotmaihet thangphaet Volume: 84 Suppl 3 ISSN: 0125-2208 ISO Abbreviation: J Med Assoc Thai Publication Date: 2001 Dec |
Date Detail:
|
Created Date: 2002-05-10 Completed Date: 2002-06-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7507216 Medline TA: J Med Assoc Thai Country: Thailand |
Other Details:
|
Languages: eng Pagination: S669-75 Citation Subset: IM |
Affiliation:
|
Department of Clinical Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angina Pectoris / microbiology, prevention & control* Anti-Bacterial Agents / therapeutic use* Chlamydophila Infections / drug therapy* Chlamydophila pneumoniae* Double-Blind Method Female Humans Male Middle Aged Myocardial Infarction / microbiology, prevention & control* Roxithromycin / therapeutic use* Treatment Failure |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 80214-83-1/Roxithromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rapid detection of Chlamydia pneumoniae DNA in peripheral blood mononuclear cells of coronary artery...
Next Document: Inexpensive, rapid and convenient PCR-minigel SSCP protocol for polymorphisms and mutations analyses...