Document Detail


Roxithromycin antagonizes catagen induction in murine and human hair follicles: implication of topical roxithromycin as hair restoration reagent.
MedLine Citation:
PMID:  18820941     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Roxithromycin (RXM) is a 14-member macrolide antibiotics, with a variety of bioregulatory functions including anti-apoptotic activity to keratinocytes. Therefore, RXM has been used for many kinds of skin diseases. In this study, human and murine hair follicles were treated with RXM in order to find the possibility to cure hair loss disease such as androgenetic alopecia (AGA). In AGA, dihydrotestosterone signals apoptosis in dermal papilla cells in susceptible individuals, resting in premature termination of anagen and early entry into catagen. Therefore, anti-apoptotitic drug has a possibility of new candidate for AGA. This study revealed RXM antagonized the in vitro inhibitory effect of IFN-gamma on proliferation of keratinocytes and induction of apoptosis in murine and human hair bulb. RXM increases hair elongation and inhibits catagen-like changes induced in vitro with IFN-gamma in murine and human hair follicles. Furthermore, topical 5% RXM solution effectively restores hair growth in about half of individuals with AGA without any local and systemic adverse effects. Therefore, RXM is new candidate as a hair restoration drug for AGA.
Authors:
Taisuke Ito; Hidekazu Fukamizu; Natsuho Ito; Naohiro Seo; Hiroaki Yagi; Masahiro Takigawa; Hideo Hashizume
Publication Detail:
Type:  Journal Article     Date:  2008-09-27
Journal Detail:
Title:  Archives of dermatological research     Volume:  301     ISSN:  1432-069X     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-27     Completed Date:  2009-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  347-55     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashi-ku, Hamamatsu 431-3192, Japan. itoutai@hama-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adult
Alopecia / drug therapy*,  pathology,  physiopathology
Animals
Apoptosis / drug effects*
Cell Growth Processes / drug effects*,  physiology
Cells, Cultured
Female
Hair Follicle / drug effects*,  pathology,  physiology
Humans
Interferon-gamma / metabolism
Mice
Mice, Inbred BALB C
Middle Aged
Roxithromycin / administration & dosage*,  adverse effects
Chemical
Reg. No./Substance:
80214-83-1/Roxithromycin; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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