Document Detail

Roxatidine in duodenal ulcer.
MedLine Citation:
PMID:  10707717     Owner:  NLM     Status:  MEDLINE    
Roxatidine acetate is a new H2-receptor antagonist. A randomized double-blind clinical trial in fifty-three patients with endoscopically proven duodenal ulcers > 5 mm in diameter was undertaken to compare safety and efficacy of roxatidine with that of ranitidine. Twenty-six patients received roxatidine (75 mg bid) while 27 patients received ranitidine (150 mg bid) for 4 weeks. One patient in each group did not come for follow up. Roxatidine and ranitidine had comparable ulcer healing rates (22/25 vs 22/26); roxatidine, however, resulted in greater reduction in the number and severity of night time pain episodes (p < 0.05). No adverse event was reported during 4 weeks of treatment with roxatidine. Thus roxatidine achieves the primary therapeutic goal of relief of pain better than ranitidine.
C M Habibullah; M A Habeeb; S P Singh
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of postgraduate medicine     Volume:  41     ISSN:  0022-3859     ISO Abbreviation:  J Postgrad Med     Publication Date:    1995 Jul-Sep
Date Detail:
Created Date:  2000-03-23     Completed Date:  2000-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985196R     Medline TA:  J Postgrad Med     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  64-5     Citation Subset:  IM    
Dept of Gastroenterology, Osmania Medical College, Osmania General Hospital, Hyderabad.
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MeSH Terms
Double-Blind Method
Drug Administration Schedule
Duodenal Ulcer / diagnosis,  drug therapy*
Follow-Up Studies
Histamine H2 Antagonists / administration & dosage*
Pain Measurement
Piperidines / administration & dosage*
Ranitidine / administration & dosage*
Treatment Outcome
Reg. No./Substance:
0/Histamine H2 Antagonists; 0/Piperidines; 66357-35-5/Ranitidine; 78628-28-1/roxatidine acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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