| Roxatidine in duodenal ulcer. | |
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MedLine Citation:
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PMID: 10707717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Roxatidine acetate is a new H2-receptor antagonist. A randomized double-blind clinical trial in fifty-three patients with endoscopically proven duodenal ulcers > 5 mm in diameter was undertaken to compare safety and efficacy of roxatidine with that of ranitidine. Twenty-six patients received roxatidine (75 mg bid) while 27 patients received ranitidine (150 mg bid) for 4 weeks. One patient in each group did not come for follow up. Roxatidine and ranitidine had comparable ulcer healing rates (22/25 vs 22/26); roxatidine, however, resulted in greater reduction in the number and severity of night time pain episodes (p < 0.05). No adverse event was reported during 4 weeks of treatment with roxatidine. Thus roxatidine achieves the primary therapeutic goal of relief of pain better than ranitidine. |
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Authors:
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C M Habibullah; M A Habeeb; S P Singh |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of postgraduate medicine Volume: 41 ISSN: 0022-3859 ISO Abbreviation: J Postgrad Med Publication Date: 1995 Jul-Sep |
Date Detail:
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Created Date: 2000-03-23 Completed Date: 2000-03-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985196R Medline TA: J Postgrad Med Country: INDIA |
Other Details:
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Languages: eng Pagination: 64-5 Citation Subset: IM |
Affiliation:
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Dept of Gastroenterology, Osmania Medical College, Osmania General Hospital, Hyderabad. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Double-Blind Method Drug Administration Schedule Duodenal Ulcer / diagnosis, drug therapy* Female Follow-Up Studies Histamine H2 Antagonists / administration & dosage* Humans Male Pain Measurement Piperidines / administration & dosage* Ranitidine / administration & dosage* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Histamine H2 Antagonists; 0/Piperidines; 66357-35-5/Ranitidine; 78628-28-1/roxatidine acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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