| Roxarsone (3-nitro-4-hydroxyphenylarsonic acid) poisoning in pigs. | |
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MedLine Citation:
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PMID: 17423588 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Young pigs, six to ten weeks of age, from two unrelated swine operations were fed a grower ration obtained from a common commercial supplier. Following ingestion of the feed for approximately two weeks, pigs in both groups developed neurological disturbances characterized by blindness, ataxia, incoordination, muscle tremors, posterior paralysis, and quadriplegia. Vocalization described as "screaming" was also observed in several animals. Necropsy findings and tissue arsenic concentrations were consistent with a diagnosis of phenylarsonic acid poisoning. The liver and kidney contained an average arsenic content of 2.9 and 1.8 mg/kg (wet weight), respectively. The feed contained 38 mg of arsenic/kg corresponding to 133 mg roxarsone (3-nitro-4-hydroxyphenylarsonic acid)/kg. This level of roxarsone is approximately three to five times higher than the levels recommended for swine rations. The feed company had placed roxarsone in the ration at levels recommended for the less toxic arsanilic acid. It was assumed that the two organic arsenicals could be added to the rations interchangeably at the same level of formulation. The present investigation indicated that roxarsone is more toxic than arsanilic acid and the margin of safety in swine rations is low. |
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Authors:
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B R Blakley; E G Clark; R Fairley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian veterinary journal. La revue vétérinaire canadienne Volume: 31 ISSN: 0008-5286 ISO Abbreviation: Can. Vet. J. Publication Date: 1990 May |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2010-06-28 Revised Date: 2010-09-15 |
Medline Journal Info:
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Nlm Unique ID: 0004653 Medline TA: Can Vet J Country: Canada |
Other Details:
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Languages: eng Pagination: 385-7 Citation Subset: - |
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