Document Detail

Routine testing of fetal Rhesus D status in Rhesus D negative women using cell-free fetal DNA: an investigation into the preferences and information needs of women.
MedLine Citation:
PMID:  23625761     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The goal of this study is to investigate women's preferences and information needs for routine implementation of fetal Rhesus D (RhD) typing using cell-free fetal DNA.
METHODS: A questionnaire was developed following focus groups and interviews with both health professionals and RhD negative (RhD-) women offered fetal RhD genotyping within a research study and distributed to RhD- women attending routine antenatal appointments in four National Health Service hospitals. Current knowledge of blood types, anti-D administration, fetal RhD genotyping and future practices were explored.
RESULTS: A total of 19 respondents participated in interviews and focus groups, and 270 respondents completed the questionnaires. Questionnaire respondents overwhelmingly felt that the test should be offered to all RhD- women (92.1%), and 75.9% said that they would accept this test. Most were happy to have the test even if it involved extra blood tests (89.3%) or appointments (79%). The knowledge of blood groups was poor. Although 90.7% knew that the baby could have a different blood group from themselves, only 34% knew that blood groups are inherited from both parents. More than 40% were not aware that anti-D would not be required if their baby was RhD-.
CONCLUSIONS: Women would welcome the introduction of routine fetal RhD genotyping. Information leaflets and training of midwives will be essential for implementation to ensure good understanding regarding testing.
Kerry Oxenford; Caroline Silcock; Melissa Hill; Lyn Chitty
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-06-20
Journal Detail:
Title:  Prenatal diagnosis     Volume:  33     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-04     Completed Date:  2014-02-11     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  688-94     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons, Ltd.
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MeSH Terms
Blood Grouping and Crossmatching / methods*
DNA / blood*
Fetal Blood / immunology*
Health Knowledge, Attitudes, Practice
Midwifery / education
Patient Education as Topic
Prenatal Diagnosis
Rh Isoimmunization / prevention & control
Rh-Hr Blood-Group System / classification*,  genetics*
Rho(D) Immune Globulin / administration & dosage
Grant Support
PB-PG-0107-12005//Department of Health
Reg. No./Substance:
0/Rh-Hr Blood-Group System; 0/Rho(D) Immune Globulin; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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