| Routine modified D2 lymphadenectomy performance in pT1-T2N0 gastric cancer. | |
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MedLine Citation:
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PMID: 19938196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate routine modified D2 lymphadenectomy in gastric cancer, based on immunohistochemically detected skip micrometastases in level II lymph nodes. METHODS: Among 95 gastric cancer patients who were routinely submitted to curative modified D2 lymphadenectomy, from January 2004 to December 2008, 32 were classified as pN0. All level I lymph nodes of these 32 patients were submitted to immunohistochemistry for micrometastases detection. Patients in whom micrometastases were detected in the level I lymph node stations (n = 4) were excluded from further analysis. The level II lymph nodes of the remaining 28 patients were studied immunohistochemically for micrometastases detection and constitute the material of the present study. RESULTS: Skip micrometastases in the level II lymph nodes were detected in 14% (4 out of 28) of the patients. The incidence was further increased to 17% (4 out of 24) in the subgroup of T1-2 gastric cancer patients. All micrometastases were detected in the No. 7 lymph node station. Thus, the disease was upstaged from stage IA to IB in one patient and from stage IB to II in three patients. CONCLUSION: In gastric cancer, true R0 resection may not be achieved without modified D2 lymphadenectomy. Until D2+/D3 lymphadenectomy becomes standard, modified D2 lymphadenectomy should be performed routinely. |
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Authors:
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John Griniatsos; Hara Gakiopoulou; Eugenia Yiannakopoulou; Nikoletta Dimitriou; Gerasimos Douridas; Afrodite Nonni; Theodoros Liakakos; Evangelos Felekouras |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 15 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2010-02-24 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 5568-72 Citation Subset: IM |
Affiliation:
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1st Department of Surgery, University of Athens, Medical School, LAIKO Hospital, Athens, Greece. johngriniatsos@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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diagnosis*,
pathology* Aged Female Humans Immunohistochemistry / methods Lymph Node Excision / methods* Lymph Nodes / pathology Lymphatic Metastasis / diagnosis* Male Middle Aged Neoplasm Staging / methods Prognosis Stomach Neoplasms / diagnosis*, pathology*, surgery Treatment Outcome |
| Comments/Corrections | |
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