Document Detail


Routine immunophenotyping in acute leukemia: Role in lineage assignment and reassignment.
MedLine Citation:
PMID:  16739218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diagnostic evaluation of acute leukemia at Roswell Park Cancer Institute has routinely included immunophenotyping by multiparameter flow cytometry. In a retrospective analysis of 646 cases, morphology and cytochemistry established lineage in 612, but not in 34 (5%), of which 26, 5, and 3 were myeloid, undifferentiated, and lymphoid, respectively, based on immunophenotyping. In addition, immunophenotyping changed the lineage assigned based on morphology and cytochemistry in 11 cases (2%); 8 changed from lymphoid to myeloid, and 3 from myeloid to lymphoid. The data support routine inclusion of at least limited immunophenotyping in the diagnostic evaluation of acute leukemia.
Authors:
Misbah Qadir; Maurice Barcos; Carleton C Stewart; Sheila N J Sait; Laurie A Ford; Maria R Baer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytometry. Part B, Clinical cytometry     Volume:  70     ISSN:  1552-4949     ISO Abbreviation:  Cytometry B Clin Cytom     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-21     Completed Date:  2006-11-14     Revised Date:  2009-12-11    
Medline Journal Info:
Nlm Unique ID:  101235690     Medline TA:  Cytometry B Clin Cytom     Country:  United States    
Other Details:
Languages:  eng     Pagination:  329-34     Citation Subset:  IM    
Copyright Information:
Copyright 2006 International Society for Analytical Cytology.
Affiliation:
Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD / metabolism
Cell Lineage*
Flow Cytometry
Humans
Immunophenotyping*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / classification*,  diagnosis*
Retrospective Studies
Tumor Markers, Biological / analysis
Grant Support
ID/Acronym/Agency:
P30 CA16056/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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