Document Detail

Routine elastic staining assists detection of vascular invasion in colorectal cancer.
MedLine Citation:
PMID:  17064294     Owner:  NLM     Status:  MEDLINE    
AIM: To determine the value of routine staining of colorectal cancer (CRC) specimens with elastic stains. METHODS AND RESULTS: Four hundred and ninety-eight cases of CRC were included. In 208 cases, vascular invasion (VI) was assessed using elastic stains [Elastic van Gieson or Elastin haematoxylin and eosin (H&E)] that were introduced as routine staining in CRC in our hospital. As a control, 290 cases in which VI was assessed solely on H&E staining were included. The site, stage and presence of vascular invasion were determined in both groups. The cost, time and workload resulting from the addition of these stains were also taken into account. The sensitivity of detection of VI in CRC was significantly improved after the introduction of these elastic stains in our routine practice (46.2% compared with 35.5% in the control group; P = 0.014). Particular improvement was noted in Dukes' stage A and B. We also noted that the net benefits gained from the introduction of these special stains outweighed the small extra cost and effort and, in addition, saved time for the reporting pathologists. CONCLUSION: Routine elastic stains are very useful and practical in evaluation of VI status in CRC and we recommend implementing these stains in routine pathological practice to improve patient care.
M Abdulkader; K Abdulla; E Rakha; P Kaye
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  49     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-26     Completed Date:  2006-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  487-92     Citation Subset:  IM    
Department of Histopathology, Queen's Medical Centre, University Hospital NHS Trust, Nottingham, UK.
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MeSH Terms
Adenocarcinoma / blood supply,  chemistry,  pathology*
Blood Vessels / chemistry,  pathology*
Colorectal Neoplasms / blood supply,  chemistry,  pathology*
Elastic Tissue / chemistry,  pathology*
Neoplasm Invasiveness / diagnosis
Sensitivity and Specificity
Staining and Labeling / methods*
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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