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Routine postoperative administration of vitamin D and calcium after total thyroidectomy: a meta-analysis.
MedLine Citation:
PMID:  20804871     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Temporary hypocalcemia is a frequent complication after total thyroidectomy. Routine postoperative administration of vitamin D and calcium can reduce the incidence of symptomatic postoperative hypocalcemia. We undertook a systematic review to assess the effectiveness of this intervention.
METHODS: We identified randomized controlled trials comparing the administration of vitamin D or metabolites to oral calcium or no treatment in patients after total thyroidectomy in MEDLINE, EMBASE and LILACS databases.
RESULTS: Four studies with 706 patients were included: 346 in the calcitriol group, 288 in the oral calcium group and 72 in the control group. The rates of hypocalcemia symptoms were 4%, 19% and 31%, respectively. The OR value for the comparison between calcitriol + calcium as compared to no treatment and to exclusive calcium treatment groups was 0.32 (95% CI, 0.13-0.79) and 0.31 (95% CI, 0.14-0.70), respectively.
CONCLUSION: The prophylactic treatment with vitamin D or metabolites + calcium is effective to decrease the incidence of symptoms of temporary hypocalcemia.
Authors:
Alvaro Sanabria; Luis C Dominguez; Valentin Vega; Camilo Osorio; Daniel Duarte
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-08
Journal Detail:
Title:  International journal of surgery (London, England)     Volume:  9     ISSN:  1743-9159     ISO Abbreviation:  Int J Surg     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101228232     Medline TA:  Int J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  46-51     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Surgery, School of Medicine, Universidad de La Sabana, Bogota, Campus Puente del Comun, Km 21 Autopista Norte, Chia, Colombia. alvarosanabria@gmail.com
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