Document Detail

Routine postoperative administration of vitamin D and calcium after total thyroidectomy: a meta-analysis.
MedLine Citation:
PMID:  20804871     Owner:  NLM     Status:  In-Process    
BACKGROUND: Temporary hypocalcemia is a frequent complication after total thyroidectomy. Routine postoperative administration of vitamin D and calcium can reduce the incidence of symptomatic postoperative hypocalcemia. We undertook a systematic review to assess the effectiveness of this intervention.
METHODS: We identified randomized controlled trials comparing the administration of vitamin D or metabolites to oral calcium or no treatment in patients after total thyroidectomy in MEDLINE, EMBASE and LILACS databases.
RESULTS: Four studies with 706 patients were included: 346 in the calcitriol group, 288 in the oral calcium group and 72 in the control group. The rates of hypocalcemia symptoms were 4%, 19% and 31%, respectively. The OR value for the comparison between calcitriol + calcium as compared to no treatment and to exclusive calcium treatment groups was 0.32 (95% CI, 0.13-0.79) and 0.31 (95% CI, 0.14-0.70), respectively.
CONCLUSION: The prophylactic treatment with vitamin D or metabolites + calcium is effective to decrease the incidence of symptoms of temporary hypocalcemia.
Alvaro Sanabria; Luis C Dominguez; Valentin Vega; Camilo Osorio; Daniel Duarte
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-08
Journal Detail:
Title:  International journal of surgery (London, England)     Volume:  9     ISSN:  1743-9159     ISO Abbreviation:  Int J Surg     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101228232     Medline TA:  Int J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  46-51     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
Department of Surgery, School of Medicine, Universidad de La Sabana, Bogota, Campus Puente del Comun, Km 21 Autopista Norte, Chia, Colombia.
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