| Routine FDG PET-CT in patients with a high-risk localized melanoma has a high predictive positive value for nodal disease and high negative predictive value for the presence of distant metastases. | |
| | |
MedLine Citation:
|
PMID: 22017492 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background FDG PET-CT is the superior imaging modality for the detection of visceral metastases (M+) in patients with melanoma. Conflicting evidence exists regarding its role for the initial staging of patients with high risk localized melanoma (large Breslow Thickness (BT) and/or ulceration). Objective To assess the role of routine staging with FDG PET-CT in melanoma patients with localized high risk melanoma. Methods Forty-eight consecutive patients with 1 < BT < 4 mm with ulceration and with BT ≥ 4 mm were staged with PET-CT. PET-CT procedures were performed on a GE Discovery ST® scanner. PET-CT findings for regional nodal status and presence of distant metastatic disease were collected. The gold standard for nodal assessment was pathological examination. The gold standard for M+ was conventional imaging and clinical follow-up, confirmed by biopsy whenever feasible. Results No patient had a positive PET-CT for M+. Six patients (13%) had a non-conclusive PET-CT; none of them presented with M+ within 6 months. Forty-three patients (90%) had a negative PET-CT, amongst them only one patient (2.5%) presented with M+ within a year. Six patients had FDG-avid lymph nodes in the drainage territory of the primary melanoma, either SLNB or lymph node dissection confirmed metastatic nodal involvement. The predictive positive value of PET for regional node involvement was 100%. Comments FDG PET-CT does not seem to be effective at detecting M+ at baseline staging in patients with high risk localized melanoma. However, it has a high negative predictive value for the presence of M+ at 6 months and a high positive predictive value for nodal involvement. |
| | |
Authors:
|
T Wagner; C Chevreau; N Meyer; L Mourey; F Courbon; S Zerdoud |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-24 |
Journal Detail:
|
Title: Journal of the European Academy of Dermatology and Venereology : JEADV Volume: - ISSN: 1468-3083 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9216037 Medline TA: J Eur Acad Dermatol Venereol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology. |
Affiliation:
|
Department of Nuclear Medicine, Purpan University Hospital, Toulouse Cedex, France Department of Nuclear Medicine, Royal Free Hospital, London, UK Department of Medical Oncology, Claudius Regaud Institute, Toulouse, France Department of Dermatology, Toulouse University Hospital, Paul-Sabatier University, Toulouse, France Department of Nuclear Medicine, Claudius Regaud Institute, Toulouse, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Coordination of a Complete Series of N(2) Reduction Intermediates (N(2)H(2), N(2)H(4), and NH(3)) to...
Next Document: NEW SPECIES OF CARDICOLA (DIGENEA: APOROCOTYLIDAE) FROM HEART OF ATLANTIC CROAKER, MICROPOGONIAS UND...