Document Detail


Rotavirus-specific antibody response in saliva of infants with rotavirus diarrhea.
MedLine Citation:
PMID:  2172405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The reliability of saliva as an indicator of rotavirus infection was assessed among 15 infants (3-12 months) with rotaviral and 15 with nonrotaviral diarrhea. Paired salivary samples collected during acute and convalescent phases were tested for rotavirus-specific IgA and IgM by an ELISA. The sensitivity of IgA or IgM alone to predict infection was 53.3% and 46.6%, respectively; used in conjunction, the sensitivity rose to 80%. It seems that infants with rotaviral diarrhea mount mucosal antibody responses as reflected in their saliva; possibly salivary antibodies could be used to evaluate vaccine "take" in rotavirus vaccine trials.
Authors:
J Aiyar; M K Bhan; N Bhandari; R Kumar; P Raj; S Sazawal
Related Documents :
9253885 - Incidence and risk factors for carbohydrate intolerance in thai infants with acute diar...
7271165 - Palatopharyngeal and lower extremity soft tissue loss in an infant secondary to pseudom...
12663295 - Oligofructose-supplemented infant cereal: 2 randomized, blinded, community-based trials...
6384455 - Oral rehydration of neonates and young infants with dehydrating diarrhea: comparison of...
568235 - Abo hemolytic disease: a comparative study of clinical severity and delayed anemia.
11324365 - Effect of sleep position on apnea and bradycardia in high-risk infants.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  162     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1990-12-21     Completed Date:  1990-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1383-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatric Gastroenterology, All India Institute of Medical Sciences, New Delhi.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antibodies, Viral / biosynthesis*
Diarrhea, Infantile / immunology*
Humans
Immunoglobulin A, Secretory / biosynthesis
Immunoglobulin M / biosynthesis
Infant
Predictive Value of Tests
Prospective Studies
Rotavirus / immunology*
Rotavirus Infections / immunology*
Saliva / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin A, Secretory; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of vaccination on serotype-specific antibody responses in infants administered WC3 bovine rot...
Next Document:  Is technetium-99 m-pyrophosphate scintigraphy valuable in the diagnosis of cardiac amyloidosis?