Document Detail

Rotavirus-specific antibody response in saliva of infants with rotavirus diarrhea.
MedLine Citation:
PMID:  2172405     Owner:  NLM     Status:  MEDLINE    
The reliability of saliva as an indicator of rotavirus infection was assessed among 15 infants (3-12 months) with rotaviral and 15 with nonrotaviral diarrhea. Paired salivary samples collected during acute and convalescent phases were tested for rotavirus-specific IgA and IgM by an ELISA. The sensitivity of IgA or IgM alone to predict infection was 53.3% and 46.6%, respectively; used in conjunction, the sensitivity rose to 80%. It seems that infants with rotaviral diarrhea mount mucosal antibody responses as reflected in their saliva; possibly salivary antibodies could be used to evaluate vaccine "take" in rotavirus vaccine trials.
J Aiyar; M K Bhan; N Bhandari; R Kumar; P Raj; S Sazawal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  162     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1990-12-21     Completed Date:  1990-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1383-4     Citation Subset:  AIM; IM    
Department of Pediatric Gastroenterology, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Antibodies, Viral / biosynthesis*
Diarrhea, Infantile / immunology*
Immunoglobulin A, Secretory / biosynthesis
Immunoglobulin M / biosynthesis
Predictive Value of Tests
Prospective Studies
Rotavirus / immunology*
Rotavirus Infections / immunology*
Saliva / immunology*
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin A, Secretory; 0/Immunoglobulin M

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