Document Detail


Rotating night shift work and the risk of ischemic stroke.
MedLine Citation:
PMID:  19357324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rotating night shift work disrupts circadian rhythms and is associated with coronary heart disease. The relation between rotating night shift work and ischemic stroke is unclear. The Nurses' Health Study, an ongoing cohort study of registered female nurses, assessed in 1988 the total number of years the nurses had worked rotating night shifts. The majority (69%) of stroke outcomes from 1988 to 2004 were confirmed by physician chart review. The authors used Cox proportional hazards models to assess the relation between years of rotating night shift work and ischemic stroke, adjusting for multiple vascular risk factors. Of 80,108 subjects available for analysis, 60% reported at least 1 year of rotating night shift work. There were 1,660 ischemic strokes. Rotating night shift work was associated with a 4% increased risk of ischemic stroke for every 5 years (hazard ratio = 1.04, 95% confidence interval: 1.01, 1.07; P(trend) = 0.01). This increase in risk was similar when limited to the 1,152 confirmed ischemic strokes (hazard ratio = 1.03, 95% confidence interval: 0.99, 1.07; P(trend) = 0.10) and may be confined to women with a history of 15 or more years of rotating shift work. Women appear to have a modestly increased risk of stroke after extended periods of rotating night shift work.
Authors:
Devin L Brown; Diane Feskanich; Brisa N Sánchez; Kathryn M Rexrode; Eva S Schernhammer; Lynda D Lisabeth
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-04-08
Journal Detail:
Title:  American journal of epidemiology     Volume:  169     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-14     Completed Date:  2009-06-16     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1370-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Chi-Square Distribution
Circadian Rhythm*
European Continental Ancestry Group
Female
Humans
Likelihood Functions
Longitudinal Studies
Middle Aged
Proportional Hazards Models
Prospective Studies
Questionnaires
Risk
Risk Factors
Sleep Disorders / epidemiology
Stroke / epidemiology*
United States / epidemiology
Work Schedule Tolerance*
Grant Support
ID/Acronym/Agency:
CA87969/CA/NCI NIH HHS; HL088521/HL/NHLBI NIH HHS; HL34594/HL/NHLBI NIH HHS; K23 NS050161/NS/NINDS NIH HHS; K23 NS051202/NS/NINDS NIH HHS; R01 HL034594/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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