Document Detail

Rosuvastatin reduces intima-media thickness in hypercholesterolemic subjects with asymptomatic carotid artery disease: the Asymptomatic Carotid Atherosclerotic Disease in Manfredonia (ACADIM) Study.
MedLine Citation:
PMID:  18778179     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: An increase in carotid intima-media thickness (CIMT) represents an early phase of the atherosclerotic process. The aim of this study was to evaluate whether a reduction in CIMT could be seen with only 16 weeks of treatment with rosuvastatin (10 mg/day). METHODS/RESULTS: Sixty-six participants of the ACADIM Study with hypercholesterolemia and carotid atherosclerosis at baseline carotid ultrasound investigation (CUI) were examined, with repeat CUI after 16 weeks of treatment. Demographic and lifestyle data were collected, as well as physical examination and fasting venous blood samples. Total cholesterol, low density lipoprotein cholesterol (LDL-C) and triglycerides decreased significantly (p < 0.0001), while high density lipoprotein cholesterol (HDL-C) increased significantly (p < 0.0001) during the intervention. The mean decrease in IMT of the right and left common carotid arteries (CCAs) was 0.35 and 0.38 mm, respectively (p < 0.05 for each). Age and lipid profile parameters were significant predictors of change in CIMT in linear regression analyses after adjustment for established atherosclerosis risk factors. CONCLUSIONS: Treatment with rosuvastatin in adults with evidence of subclinical atherosclerosis significantly reduced the CIMT of both CCAs, as well as improving lipid and lipoprotein levels.
Graziano Riccioni; Lydia A Bazzano; Tonino Bucciarelli; Barbara Mancini; Emanuela di Ilio; Nicolantonio D'Orazio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  9     ISSN:  1744-7666     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-09     Completed Date:  2008-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  England    
Other Details:
Languages:  eng     Pagination:  2403-8     Citation Subset:  IM    
San Camillo de Lellis' Hospital, Cardiology Unit, Manfredonia, Foggia, Italy.
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MeSH Terms
Atherosclerosis / complications*
Carotid Artery Diseases / complications*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Cross-Sectional Studies
Fluorobenzenes / adverse effects,  pharmacology*,  therapeutic use
Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects,  pharmacology,  therapeutic use*
Hypercholesterolemia / complications,  drug therapy*
Middle Aged
Prospective Studies
Pyrimidines / adverse effects,  pharmacology*,  therapeutic use
Sulfonamides / adverse effects,  pharmacology*,  therapeutic use
Triglycerides / blood
Tunica Intima / drug effects*
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Fluorobenzenes; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrimidines; 0/Sulfonamides; 0/Triglycerides; 287714-41-4/rosuvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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