| Rosuvastatin-acenocoumarol interaction. | |
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MedLine Citation:
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PMID: 16117985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previous evidence suggests that hydroxymethylglutaryl coenzyme A-reductase inhibitors (statins) might potentiate the effect of oral anticoagulants, but a MEDLINE search (key terms: stains, rosuvastatin, anticoagulants, acenocoumarol, and interaction; years: 1980-2005) revealed no reports of an interaction between rosuvastatin and acenocoumarol. OBJECTIVE: The aim of this article was to describe a case of possible interaction between rosuvastatin and acenocoumarol. METHODS: We report the case of a 36-year-old male patient receiving long-term oral treatment with acenocoumarol, a synthetic coumarin anticoagulant, who experienced an increase in international normalized ratio (INR) and a hematoma in the left leg approximately 45 days after the initiation of treatment with rosuvastatin. RESULTS: After discontinuation of both drugs, an unexpectedly rapid decrease in INR was observed. CONCLUSIONS: Based on the results of this case, a possible pharmacologic interaction between rosuvastatin and acenocoumarol should be considered. Rosuvastatin might enhance the anticoagulant effect of acenocoumarol, and a rebound effect in cases of simultaneous discontinuation of both drugs might occur. Rosuvastatin should be administered with extreme caution in patients receiving long-term acenocoumarol therapy. |
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Authors:
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Sergio Mondillo; Piercarlo Ballo; Maurizio Galderisi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical therapeutics Volume: 27 ISSN: 0149-2918 ISO Abbreviation: Clin Ther Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-08-24 Completed Date: 2006-05-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: United States |
Other Details:
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Languages: eng Pagination: 782-4 Citation Subset: IM |
Affiliation:
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Division of Cardiology, University of Siena, Italy. mondillo@unisi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acenocoumarol
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administration & dosage,
adverse effects*,
therapeutic use Administration, Oral Adult Anticoagulants / administration & dosage, adverse effects, therapeutic use Drug Interactions Drug Therapy, Combination Fluorobenzenes / administration & dosage, adverse effects*, therapeutic use Hematoma / chemically induced Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage, adverse effects, therapeutic use International Normalized Ratio Leg Male Pyrimidines / administration & dosage, adverse effects*, therapeutic use Sulfonamides / administration & dosage, adverse effects*, therapeutic use Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Fluorobenzenes; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrimidines; 0/Sulfonamides; 152-72-7/Acenocoumarol; 287714-41-4/rosuvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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