Document Detail

Rosuvastatin-acenocoumarol interaction.
MedLine Citation:
PMID:  16117985     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous evidence suggests that hydroxymethylglutaryl coenzyme A-reductase inhibitors (statins) might potentiate the effect of oral anticoagulants, but a MEDLINE search (key terms: stains, rosuvastatin, anticoagulants, acenocoumarol, and interaction; years: 1980-2005) revealed no reports of an interaction between rosuvastatin and acenocoumarol. OBJECTIVE: The aim of this article was to describe a case of possible interaction between rosuvastatin and acenocoumarol. METHODS: We report the case of a 36-year-old male patient receiving long-term oral treatment with acenocoumarol, a synthetic coumarin anticoagulant, who experienced an increase in international normalized ratio (INR) and a hematoma in the left leg approximately 45 days after the initiation of treatment with rosuvastatin. RESULTS: After discontinuation of both drugs, an unexpectedly rapid decrease in INR was observed. CONCLUSIONS: Based on the results of this case, a possible pharmacologic interaction between rosuvastatin and acenocoumarol should be considered. Rosuvastatin might enhance the anticoagulant effect of acenocoumarol, and a rebound effect in cases of simultaneous discontinuation of both drugs might occur. Rosuvastatin should be administered with extreme caution in patients receiving long-term acenocoumarol therapy.
Sergio Mondillo; Piercarlo Ballo; Maurizio Galderisi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical therapeutics     Volume:  27     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-08-24     Completed Date:  2006-05-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  782-4     Citation Subset:  IM    
Division of Cardiology, University of Siena, Italy.
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MeSH Terms
Acenocoumarol / administration & dosage,  adverse effects*,  therapeutic use
Administration, Oral
Anticoagulants / administration & dosage,  adverse effects,  therapeutic use
Drug Interactions
Drug Therapy, Combination
Fluorobenzenes / administration & dosage,  adverse effects*,  therapeutic use
Hematoma / chemically induced
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage,  adverse effects,  therapeutic use
International Normalized Ratio
Pyrimidines / administration & dosage,  adverse effects*,  therapeutic use
Sulfonamides / administration & dosage,  adverse effects*,  therapeutic use
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Anticoagulants; 0/Fluorobenzenes; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrimidines; 0/Sulfonamides; 152-72-7/Acenocoumarol; 287714-41-4/rosuvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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