| Rostral migratory stream neuroblasts turn and change directions in stereotypic patterns. | |
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MedLine Citation:
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PMID: 21045564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuroblasts generated in the adult subventricular zone (SVZ) migrate through the rostral migratory stream (RMS) to the olfactory bulb (OB). Previous work uncovered motility ranging from straight to complex, but it was unclear if directional changes were stochastic or exhibited stereotypical patterns. Here, we provide the first in-depth two-photon time-lapse microscopy study of morphological and dynamic features that accompany turning and direction reversals in the RMS. We identified three specific kinds of turning (30-90 degrees): bending of the leading process proximal to the cell body (P-bending 47% of cases), bending of the distal leading process (D-bending 30%) or branching of the leading process or lamellipodium (23%). Bending and branching angles were remarkably constrained and were significantly different from one another. Cells reversed direction (> 90 degrees) through D-bendings (54%), branching (11%) or de novo growth of processes from the soma (23%), but not P-bending. Direction reversal was often composed of several iterations of D-bending or branching as opposed to novel modalities. Individual neuroblasts could turn or change direction in multiple patterns suggesting that the patterns are not specific for different lineages. These findings show that neuroblasts in the RMS use a limited number of distinct and constrained modalities to turn or reverse direction. |
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Authors:
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Noelia Martinez-Molina; Yongsoo Kim; Philip Hockberger; Francis G Szele |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-01 |
Journal Detail:
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Title: Cell adhesion & migration Volume: 5 ISSN: 1933-6926 ISO Abbreviation: Cell Adh Migr Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2011-01-28 Completed Date: 2011-04-18 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 101469464 Medline TA: Cell Adh Migr Country: United States |
Other Details:
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Languages: eng Pagination: 83-95 Citation Subset: IM |
Affiliation:
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Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / cytology*, physiology* Cell Movement / physiology* Cerebral Ventricles Female Male Mice Mice, Inbred C57BL Mice, Transgenic Neural Stem Cells / cytology*, metabolism* Neurogenesis Neurons / cytology*, physiology Olfactory Bulb Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS/AG42253-01/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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