Document Detail

Rosmarinic acid.
MedLine Citation:
PMID:  12482446     Owner:  NLM     Status:  MEDLINE    
Rosmarinic acid is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid. It is commonly found in species of the Boraginaceae and the subfamily Nepetoideae of the Lamiaceae. However, it is also found in species of other higher plant families and in some fern and hornwort species. Rosmarinic acid has a number of interesting biological activities, e.g. antiviral, antibacterial, antiinflammatory and antioxidant. The presence of rosmarinic acid in medicinal plants, herbs and spices has beneficial and health promoting effects. In plants, rosmarinic acid is supposed to act as a preformed constitutively accumulated defence compound. The biosynthesis of rosmarinic acid starts with the amino acids L-phenylalanine and L-tyrosine. All eight enzymes involved in the biosynthesis are known and characterised and cDNAs of several of the involved genes have been isolated. Plant cell cultures, e.g. from Coleus blumei or Salvia officinalis, accumulate rosmarinic acid in amounts much higher than in the plant itself (up to 36% of the cell dry weight). For this reason a biotechnological production of rosmarinic acid with plant cell cultures has been proposed.
Maike Petersen; Monique S J Simmonds
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Phytochemistry     Volume:  62     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-16     Completed Date:  2003-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  121-5     Citation Subset:  IM    
Institut für Pharmazeutische Biologie, Philipps-Universität Marburg, Deutschhausstr. 17A, D-35037 Marburg, Germany.
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MeSH Terms
Boraginaceae / chemistry,  metabolism
Cinnamates / chemistry*,  metabolism,  pharmacology
Lamiaceae / chemistry,  metabolism
Molecular Structure
Plants, Medicinal / chemistry,  metabolism
Reg. No./Substance:
0/Cinnamates; 0/Depsides; 537-15-5/rosmarinic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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