Document Detail


Rosiglitazone treatment alleviates inflammation and improves liver function in overweight women with polycystic ovary syndrome: a randomized placebo-controlled study.
MedLine Citation:
PMID:  17074328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a randomized, placebo-controlled study, we studied the effects of 4 months' treatment with rosiglitazone on low-grade inflammation, liver function, lipid levels, and blood pressure in 30 overweight women with polycystic ovary syndrome. Rosiglitazone significantly decreased serum C-reactive protein levels, white blood cell count, and alanine aminotransferase enzyme activity but did not affect lipid or blood pressure levels. Placebo had no effect on any parameters.
Authors:
Katrina Rautio; Juha S Tapanainen; Aimo Ruokonen; Laure C Morin-Papunen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-10-30
Journal Detail:
Title:  Fertility and sterility     Volume:  87     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  202-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University Hospital of Oulu, Oulu, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Female
Humans
Hypoglycemic Agents / administration & dosage
Inflammation / drug therapy*
Liver Diseases / drug therapy*
Obesity / drug therapy*
Polycystic Ovary Syndrome / drug therapy*
Thiazolidinediones / therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Hypoglycemic Agents; 0/Thiazolidinediones; 122320-73-4/rosiglitazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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