Document Detail


Rosiglitazone regulates IL-6-stimulated lipolysis in porcine adipocytes.
MedLine Citation:
PMID:  20921996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin (IL)-6, a proinflammatory cytokine, stimulates adipocyte lipolysis and induces insulin resistance in obese and diabetic subjects. However, the effects of the anti-diabetic drug rosiglitazone on IL-6-stimulated lipolysis and the underlying molecular mechanism are largely unknown. In this study, we demonstrated that rosiglitazone suppressed IL-6-stimulated lipolysis in differentiated porcine adipocytes by inactivation of extracellular signal-related kinase (ERK). Meanwhile, rosiglitazone enhanced the lipolysis response of adipocytes to isoprenaline. In addition, rosiglitazone significantly reversed IL-6-induced down-regulation of several genes such as perilipin A, peroxisome proliferators activated receptor gamma (PPARγ), and fatty acid synthetase, as well as the up-regulation of IL-6 mRNA. However, mRNA expression of PPARγ coactivator-1 alpha (PCG-1α) was enhanced by rosiglitazone in IL-6-stimulated adipocytes. These results indicate that rosiglitazone suppresses IL-6-stimulated lipolysis in porcine adipocytes through multiple molecular mechanisms.
Authors:
Yongqing Yang; Gongshe Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemistry and cell biology = Biochimie et biologie cellulaire     Volume:  88     ISSN:  1208-6002     ISO Abbreviation:  Biochem. Cell Biol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2011-02-08     Revised Date:  2011-10-17    
Medline Journal Info:
Nlm Unique ID:  8606068     Medline TA:  Biochem Cell Biol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  853-60     Citation Subset:  IM    
Affiliation:
College of Life Science, Shanxi Normal University, Linfen, Shanxi Province 041000, People's Republic of China. yyqing71@163.com
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / cytology,  drug effects*,  metabolism
Animals
Blotting, Western
Cells, Cultured
Female
Hypoglycemic Agents / pharmacology*
Interleukin-6 / antagonists & inhibitors*,  pharmacology
Lipolysis / drug effects*
Male
PPAR gamma / genetics,  metabolism
Phosphoproteins / genetics,  metabolism
RNA, Messenger / genetics
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
Swine
Thiazolidinediones / pharmacology*
Up-Regulation
Chemical
Reg. No./Substance:
0/Hypoglycemic Agents; 0/Interleukin-6; 0/PPAR gamma; 0/Phosphoproteins; 0/RNA, Messenger; 0/Thiazolidinediones; 0/perilipin 1; 122320-73-4/rosiglitazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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