Document Detail

Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, decreases immunoreactivity of markers for cell proliferation and neuronal differentiation in the mouse hippocampus.
MedLine Citation:
PMID:  20298677     Owner:  NLM     Status:  MEDLINE    
In the present study, we investigated the regulating effects of rosiglitazone (RSG), a synthetic agonist of peroxisome proliferator-activated receptor gamma, treatment for 28days on the cell proliferation and neuronal differentiation in the mouse hippocampal dentate gyrus by 5-bromo-2'-deoxyuridine (BrdU), Ki67 and doublecortin (DCX) immunohistochemistry. These markers were detected in the subgranular zone (SGZ) of the dentate gyrus in vehicle- and RSG-treated groups. In the RSG-treated group, the number of BrdU-, Ki67- and DCX-immunoreactive cells was significantly decreased compared to those in the vehicle-treated group. In addition, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor levels were significantly decreased in the dentate gyrus of the RSG-treated groups compared to the vehicle-treated group. These results indicate that RSG treatment decreases immunoreactivities of markers for cell proliferation and neuronal differentiation and levels of neurotrophic factors in the SGZ of the hippocampal dentate gyrus.
Choong Hyun Lee; Jung Hoon Choi; Ki-Yeon Yoo; Ok Kyu Park; Joong Bum Moon; Youdong Sohn; Jun Hwi Cho; In Koo Hwang; Moo-Ho Won
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-15
Journal Detail:
Title:  Brain research     Volume:  1329     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  30-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon 200-702, South Korea.
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MeSH Terms
Biological Markers / metabolism
Brain-Derived Neurotrophic Factor / metabolism
Bromodeoxyuridine / metabolism
Cell Differentiation / drug effects
Cell Proliferation / drug effects
Dentate Gyrus / cytology*,  drug effects,  metabolism
Glial Cell Line-Derived Neurotrophic Factor / metabolism
Hypoglycemic Agents / pharmacology*
Ki-67 Antigen / metabolism
Mice, Inbred ICR
Microtubule-Associated Proteins / metabolism
Neurons / drug effects*,  metabolism
Neuropeptides / metabolism
PPAR gamma / agonists*
Stem Cells / drug effects*,  metabolism
Thiazolidinediones / pharmacology*
Reg. No./Substance:
0/Biological Markers; 0/Brain-Derived Neurotrophic Factor; 0/Glial Cell Line-Derived Neurotrophic Factor; 0/Hypoglycemic Agents; 0/Ki-67 Antigen; 0/Microtubule-Associated Proteins; 0/Neuropeptides; 0/PPAR gamma; 0/Thiazolidinediones; 0/doublecortin protein; 122320-73-4/rosiglitazone; 59-14-3/Bromodeoxyuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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