| Rosiglitazone aggravates nonalcoholic Fatty pancreatic disease in C57BL/6 mice fed high-fat and high-sucrose diet. | |
| | |
MedLine Citation:
|
PMID: 19214135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Evaluate the effect of fenofibrate, bezafibrate, and rosiglitazone on nonalcoholic fatty pancreatic disease and islet peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-beta immunostain in mice fed high-fat high-sucrose (HFHS) diet. METHODS: Two-month-old male mice were fed standard chow (n = 10) or HFHS chow (n = 40) for 6 weeks. Afterward, HFHS mice were grouped by treatment: untreated HFHS and HFHS treated with rosiglitazone (HFHS-Ro), fenofibrate (HFHS-Fe), or bezafibrate (HFHS-Bz). Medications were administered for 5 weeks. After treatment, the pancreas was removed and analyzed by morphometry, stereology, and immunohistochemistry. RESULTS: The HFHS-fed mice showed altered fasting glucose (+33%) and insulin (+138%); increased body (+20%) and pancreas (+28%) masses, pancreatic fat (+700%), islet hypertrophy (+38%); and decreased GLUT2 immunostain (-60%). Rosiglitazone reduced fasting glucose and insulin but induced weight gain. Fibrates impeded weight gain, but only bezafibrate prevented islet hypertrophy. The GLUT2 stain was improved in all treatments, and there were no alterations in PPAR-alpha. There were morphological signs of pancreatitis with fenofibrate, although there were no alterations in amylase and lipase. Rosiglitazone exacerbated pancreatic fat infiltration (+75% vs HFHS group), and bezafibrate increased PPAR-beta expression in pancreatic islets. CONCLUSIONS: Rosiglitazone is shown for the first time to exacerbate pancreatic fat infiltration; therefore, precaution has to be taken when rosiglitazone is prescribed to obese patients. |
| | |
Authors:
|
Caroline Fernandes-Santos; Rafael Evangelista Carneiro; Leonardo de Souza Mendonca; Márcia Barbosa Aguila; Carlos Alberto Mandarim-de-Lacerda |
Related Documents
:
|
17316855 - Episodic stress associated with writing a graduation thesis and free cortisol secretion... 7165505 - Investigations on the amino acid secretion and absorption in the stomach of the growing... 19167915 - Lipid metabolism and hyperlipidemia in dogs. 2643485 - Modulation of dietary fat-promoted pancreatic carcinogenesis in rats and hamsters by ch... 6706215 - The ileal brake--inhibition of jejunal motility after ileal fat perfusion in man. 2731495 - Reduced thermoregulatory thermogenesis in undernutrition. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pancreas Volume: 38 ISSN: 1536-4828 ISO Abbreviation: Pancreas Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-03-25 Completed Date: 2009-05-18 Revised Date: 2009-09-03 |
Medline Journal Info:
|
Nlm Unique ID: 8608542 Medline TA: Pancreas Country: United States |
Other Details:
|
Languages: eng Pagination: e80-6 Citation Subset: IM |
Affiliation:
|
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
pathology Animals Antilipemic Agents / pharmacology Bezafibrate / pharmacology Blood Glucose / metabolism Diabetes Mellitus, Type 2 / drug therapy Dietary Fats / pharmacology* Dietary Sucrose / pharmacology* Energy Metabolism / drug effects Hypoglycemic Agents / toxicity* Insulin / blood Male Mice Mice, Inbred C57BL Obesity / drug therapy PPAR alpha / metabolism PPAR-beta / metabolism Pancreatic Diseases / chemically induced*, metabolism, pathology Procetofen / pharmacology Thiazolidinediones / toxicity* Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Antilipemic Agents; 0/Blood Glucose; 0/Dietary Fats; 0/Dietary Sucrose; 0/Hypoglycemic Agents; 0/PPAR alpha; 0/PPAR-beta; 0/Thiazolidinediones; 11061-68-0/Insulin; 122320-73-4/rosiglitazone; 41859-67-0/Bezafibrate; 49562-28-9/Procetofen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluating the association between anxiety and satisfaction.
Next Document: Serum heat shock protein 27 is increased in chronic pancreatitis and pancreatic carcinoma.