Document Detail

Rosai-Dorfman disease isolated to the central nervous system: a report of six cases.
MedLine Citation:
PMID:  19703267     Owner:  NLM     Status:  MEDLINE    
We reviewed the diagnosis and treatment of six patients with CNS Rosai-Dorfman disease (RDD). Lesions were located in the cerebral convexity, middle cranial base, parasaggital, petrous orbit, and thoracic spine. Preoperatively, all the lesions were misdiagnosed as meningioma. Histopathology of all CNS lesions showed a characteristic feature called emperipolesis, where small lymphocytes or plasma cells were engulfed in histiocyte cytoplasm. Total resection of lesions was performed in all cases, and at an average follow-up of 15 months, all patients are alive and well with no evidence of recurrence. Preoperative diagnosis of CNS RDD is challenging. Surgical removal of lesions is an effective treatment. More research is needed to clarify the effectiveness of other treatment options such as radiosurgery and corticosteroid therapy.
Yin Wang; Xiang Gao; Weijun Tang; Chengchuan Jiang
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-08-23
Journal Detail:
Title:  Neuropathology : official journal of the Japanese Society of Neuropathology     Volume:  30     ISSN:  1440-1789     ISO Abbreviation:  Neuropathology     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606526     Medline TA:  Neuropathology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  154-8     Citation Subset:  IM    
Department of Neuropathology, Hua-shan Hospital, Shanghai, China.
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MeSH Terms
Brain / pathology*
Central Nervous System Diseases / pathology*,  surgery
Diagnosis, Differential
Histiocytosis, Sinus / pathology*,  surgery
Medical Records
Meningioma / pathology
Middle Aged
Spinal Cord / pathology*
Thoracic Vertebrae
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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