Document Detail


Rosacea, reactive oxygen species, and azelaic Acid.
MedLine Citation:
PMID:  20967185     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Rosacea is a common skin condition thought to be primarily an inflammatory disorder. Neutrophils, in particular, have been implicated in the inflammation associated with rosacea and mediate many of their effects through the release of reactive oxygen species. Recently, the role of reactive oxygen species in the pathophysiology of rosacea has been recognized. Many effective agents for rosacea, including topical azelaic acid and topical metronidazole, have anti-inflammatory properties. in-vitro models have demonstrated the potent antioxidant effects of azelaic acid, providing a potential mechanistic explanation for its efficacy in the treatment of rosacea.
Authors:
David A Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical and aesthetic dermatology     Volume:  2     ISSN:  1941-2789     ISO Abbreviation:  J Clin Aesthet Dermatol     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2010-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101518173     Medline TA:  J Clin Aesthet Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26-30     Citation Subset:  -    
Affiliation:
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts.
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