| Rosacea: The cytokine and chemokine network. | |
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MedLine Citation:
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PMID: 22076326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rosacea is one of the most common dermatoses of adults. Recent studies have improved our understanding of the pathophysiology of rosacea. Current concepts suggest that known clinical trigger factors of rosacea such as UV radiation, heat, cold, stress, spicy food, and microbes modulate Toll-like receptor signaling, induce reactive oxygen species, as well as enhance antimicrobial peptide and neuropeptide production. Downstream of these events cytokines and chemokines orchestrate an inflammatory response that leads to the recruitment and activation of distinct leukocyte subsets and induces the characteristic histopathological features of rosacea. Here we summarize the current knowledge of the cytokine and chemokine network in rosacea and propose pathways that may be of therapeutic interest. |
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Authors:
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Peter Arne Gerber; Bettina Alexandra Buhren; Martin Steinhoff; Bernhard Homey |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research Volume: 15 ISSN: 1529-1774 ISO Abbreviation: J. Investig. Dermatol. Symp. Proc. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-14 Completed Date: 2012-02-23 Revised Date: 2012-05-09 |
Medline Journal Info:
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Nlm Unique ID: 9609059 Medline TA: J Investig Dermatol Symp Proc Country: United States |
Other Details:
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Languages: eng Pagination: 40-7 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University Hospital Düsseldorf, Düsseldorf, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cytokines / immunology, metabolism* Dermatologic Agents / immunology, therapeutic use Humans Immunity, Innate Reactive Oxygen Species / adverse effects, immunology Receptor, Epidermal Growth Factor / immunology, physiology Rosacea / drug therapy, immunology* Signal Transduction / immunology Skin / blood supply, immunology, physiopathology Toll-Like Receptors / immunology Ultraviolet Rays / adverse effects |
| Grant Support | |
ID/Acronym/Agency:
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R01 AR059402/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Dermatologic Agents; 0/Reactive Oxygen Species; 0/Toll-Like Receptors; EC 2.7.10.1/Receptor, Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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