Document Detail

Ropivacaine in peribulbar anesthesia - vasoconstrictive properties.
MedLine Citation:
PMID:  20863930     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Peribulbar anesthesia can reduce ocular blood flow (OBF) by increasing intraocular pressure (IOP) or due to the action of drugs. Ropivacaine has low toxicity and intrinsic vasoconstrictive properties, yet to be proven on the ocular vasculature. Measurements of ocular pulse amplitude (OPA) allow the indirect evaluation of the OBF. The objective of the present study was to evaluate through the OBF the vasoconstrictive properties of ropivacaine in peribulbar anesthesia.
METHODS: Forty eyes undergoing peribulbar anesthesia with 7 mL of anesthetic solution without vasoconstrictor were randomly divided into two groups: ropivacaine (n = 20) and bupivacaine (n = 20). The IOP, ocular perfusion pressure (OPP), OPA, hemodynamic parameters, and the degree of akinesia before and 5 and 10 minutes after the blockade were evaluated. A dynamic contour tonometer was used to evaluate ocular parameters. Sedation was similar in both groups.
RESULTS: A significant variation in hemodynamic parameters and intensity of the motor blockade was not observed between groups. Differences in IOP, OPP, and OPA (p < 0.05) were observed between both groups at 5 and 10 minutes. The variation of IOP at 5 and 10 minutes was -0.88% and -4.54%, respectively with ropivacaine, and 17.61% and 16.56% with bupivacaine. The change in OPP after 5 and 10 minutes was 1.5% and 4.2% with ropivacaine, and -7% and -6% with bupivacaine. Ocular pulse amplitude varied -55.59% and -59.67% with ropivacaine at 5 and 10 minutes, and -34.71% and -28.82% with bupivacaine.
CONCLUSIONS: Ropivacaine reduced more intensely the ocular pulse amplitude despite little changes in IOP and OPP. The reduction in ocular blood flow caused by ropivacaine can be attributed to its vasoconstrictive effect.
Catia Sousa Govêia; Edno Magalhães
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Revista brasileira de anestesiologia     Volume:  60     ISSN:  1806-907X     ISO Abbreviation:  Rev Bras Anestesiol     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-09-24     Completed Date:  2011-03-03     Revised Date:  2014-02-05    
Medline Journal Info:
Nlm Unique ID:  0401316     Medline TA:  Rev Bras Anestesiol     Country:  Brazil    
Other Details:
Languages:  eng; por     Pagination:  495-512     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Editora Ltda. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amides / therapeutic use*
Anesthetics, Local / therapeutic use*
Bupivacaine / therapeutic use*
Conjunctiva / transplantation
Double-Blind Method
Eye / blood supply*
Prospective Studies
Pterygium / surgery
Regional Blood Flow / drug effects
Vasoconstriction / drug effects*
Reg. No./Substance:
0/Amides; 0/Anesthetics, Local; 7IO5LYA57N/ropivacaine; Y8335394RO/Bupivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A comparative study between bupivacaine (S75-R25) and ropivacaine in spinal anesthesia for labor ana...
Next Document:  Utility of transesophageal echocardiography during severe hypotension in non-cardiac surgery.