Document Detail

Root replacement for all allograft aortic valves: preferred technique or too radical?
MedLine Citation:
PMID:  7646217     Owner:  NLM     Status:  MEDLINE    
From November 1985 to January 1994, 146 patients have received a viable cryopreserved allograft for aortic root replacement. The follow-up was complete, with all events included to March 1st, 1994. The median age of patients was 49 years; 83.6% were male. Valve dysfunction (91 patients), primary aortic wall disease (45 patients), and a combination of both (10 patients) were the indications for aortic root replacement. The current operative mortality is 1.7% (three deaths in 172 patients to July 1st, 1994). Four late deaths have occurred, with an 8-year actuarial survival of 85% +/- 8% (95% confidence limits). Endocarditis (two events) and thromboembolism (four events) had a low incidence. Structural deterioration (three events) and reoperation for all causes (nine events) have constituted low morbidity and are compared with the results after non-root allograft implantation techniques. The clinical and echocardiographic evidence indicates that the immediate results of valve function with root replacement are superior. But no statistical difference between aortic root replacement and non-root procedures is apparent at 8 years, indicating that a longer follow-up is required before the answer to the question "preferred technique or too radical" can be answered.
M F O'Brien; R S Finney; E G Stafford; M A Gardner; P G Pohlner; P J Tesar; A D Cochrane; K L Gall; S E Smith
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  60     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-20     Completed Date:  1995-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S87-91     Citation Subset:  AIM; IM    
Department of Cardiac Surgery, Prince Charles Hospital, Brisbane, Australia.
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MeSH Terms
Aorta / surgery
Aortic Valve / transplantation*
Endocarditis / etiology
Middle Aged
Postoperative Complications
Survival Analysis
Thromboembolism / etiology
Transplantation, Homologous / methods,  mortality

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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